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Multi-scale Nano/Micro Fiber Scaffolds with Different Topological Morphologies

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Abstract

The multi-scale fiber and topological morphologies had been shown to influence cell mitogenesis and chemotaxis, direct cell differentiation, and induce constructive host tissue remodeling responses. To simulate multi-layer meshwork architecture of extracellular matrix and regulate cell behavior, we prepared different topological scaffolds, such as 3D printing fiber scaffolds, poly(lactic acid) (PLA) electrospun fiber scaffolds, 3D printing/knitted fabric composite scaffolds, and PLA electrospinning/knitted fabric composite scaffolds. The surface morphology, pore diameter, thickness, stress-strain curve, electrical current, and other properties were studied. The aim is to prepare multi-scale nano/micro fiber scaffolds with different topological morphologies and properties that can provide structural and mechanical support for potential tissue engineering applications.

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Acknowledgement

We want to thank Chenyao Zheng and Wenjie Yu for their contributions. This research was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LY20E030004 and Zhejiang Sci-Tech University Scientific Research Project under Grant No. 2019Q025.

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Authors and Affiliations

  1. College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Jianyong Feng, Ruixiang Xu & Jiaming Zhao

  2. Hangzhou Deefine Filtration Technology Co., Ltd., Research and Development Center of Electrospinning Fibers, Hangzhou, 311122, China

    Lingxiao Zhang

Authors
  1. Jianyong Feng
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  2. Ruixiang Xu
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  3. Jiaming Zhao
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  4. Lingxiao Zhang
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Correspondence to Jianyong Feng.

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Feng, J., Xu, R., Zhao, J. et al. Multi-scale Nano/Micro Fiber Scaffolds with Different Topological Morphologies. Fibers Polym 23, 935–943 (2022). https://doi.org/10.1007/s12221-022-4374-y

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  • DOI: https://doi.org/10.1007/s12221-022-4374-y

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