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Experimental study of ultrasound-triggered vaporization of microdroplets on a wall

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Abstract

Ultrasound-triggered vaporization of dodecafluoropentane (DDFP) droplets has great potential for local drug delivery, especially when in contact with target tissues or areas to be treated. The dynamic motion of phase-changing (PC) droplets on a wall was experimentally investigated using high speed imaging and compared to non-phase-changing (NPC) bubble motion. Micro-sized PC droplets and NPC bubbles were exposed to ultrasound pulses of 0.6–3 MPa at 5 MHz as conditions that satisfy the FDA recommended mechanical index. The volume expansion due to phase change was found to promote the detachment of PC droplets from the wall. The effects of droplet or bubble size and ultrasound amplitude on the dynamic motion of PC droplets and NPC bubbles were quantified.

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF), funded by the Korean government (MSIP) (Grant No. 2019R1AC2004109).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 04107, Korea

    Seho Kwon & Gihun Son

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  1. Seho Kwon
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  2. Gihun Son
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Correspondence to Gihun Son.

Additional information

Seho Kwon received his B.S. and M.S. in Mechanical Engineering from Sogang University in Seoul, Korea in 2016 and 2021, where he is currently a Ph.D. student in Mechanical Engineering. Kwon’s research interests include microfluidics and multiphase dynamics with phase change.

Gihun Son received his B.S. and M.S. in Mechanical Engineering from Seoul National University in 1986 and 1988, respectively, and his Ph.D. from UCLA in 1996. Dr. Son is currently a Professor of Mechanical Engineering at Sogang University, Korea. His research interests include heat transfer, multiphase flows and power plants.

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Kwon, S., Son, G. Experimental study of ultrasound-triggered vaporization of microdroplets on a wall. J Mech Sci Technol 36, 1329–1335 (2022). https://doi.org/10.1007/s12206-022-0222-7

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  • DOI: https://doi.org/10.1007/s12206-022-0222-7

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