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Diagnostics of bronchopulmonary diseases through Mahalanobis distance-based absorption spectral analysis of exhaled air

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Abstract

Accurate diagnosis of different bronchopulmonary diseases is important in clinical practice. This study involved 20 healthy volunteers and 77 patients with bronchopulmonary diseases, including chronic obstructive pulmonary disease (COPD), bronchial asthma, pulmonary tuberculosis, and community-acquired pneumonia. The absorption spectrum of exhaled air samples was recorded on an intra-cavity photo-acoustic gas analyzer (ILPA-1, Special Technologies, Ltd., Russia) with photo-acoustic detectors and CO2 laser with a tuning range from 9.2 to 10.8 μm. In conclusion, analysis of the Mahalanobis distance-based absorption spectral profiles of breath air from bronchopulmonary patients and healthy volunteers allows the formulation of a preliminary diagnosis.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk, 634050, Russia

    A. A. Bulanova, E. B. Bukreeva & Yu. V. Kistenev

  2. Tomsk State University, Tomsk, 634050, Russia

    Yu. V. Kistenev

  3. V.E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk, 634055, Russia

    O. Yu. Nikiforova

Authors
  1. A. A. Bulanova
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  2. E. B. Bukreeva
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  3. Yu. V. Kistenev
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  4. O. Yu. Nikiforova
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Corresponding author

Correspondence to A. A. Bulanova.

Additional information

A. A. Bulanova is the leading specialist in the pulmonology department of the State Clinical Hospital No. 3 of Tomsk City. She graduated from the Medical Faculty of the Siberian State Medical University (Tomsk, Russia) in 2009 and obtained a post-graduate specialty in pulmonology.

In 2011, she took the first step into science in the Department of Therapy in the Siberian State Medical University, where together with her scientific adviser, Prof. Bukreeva. Her research interests are the early diagnosis of chronic obstructive pulmonary disease (COPD) and other bronchopulmonary diseases.

E. B. Bukreeva graduated from the Medical Faculty of the Siberian State Medical University (Tomsk, Russia) in 1975 and received a Ph.D. degree in medical sciences in 1988. In 2005, she received her Ph.D. degree of medical sciences.

She is currently a professor in the therapy department at the pediatric faculty in the Siberian State Medical University. Her research interests are pneumology and clinical pharmacology. She studies etiology of inflammation in chronic obstructive pulmonary disease (COPD), genetic causes of COPD, and problems of early diagnosis of COPD and other bronchopulmonary diseases.

Yu. V. Kistenev graduated from the Radio-Physical Faculty of Tomsk State University, and received his Ph.D. degree in optics.

His work experience: engineer of laboratory of optical waves of Siberian Physical-Technical Institute of Tomsk State University (1982–1984), postgraduate student of the radio-physics department of Tomsk State University (1984–1987), research assistant at the laboratory of optical waves of Siberian Physical-Technical Institute of Tomsk State University (1987–1993), doctoral student of the radio-physics department of Tomsk State University (1993–1996), senior researcher at the laboratory of atmospheric absorption spectroscopy of The Institute of Atmospheric Optics (1996–1999), head of the physical department of Siberian State Medical University (1999-present (2014-part-time work at present)), Deputy Vice Rector for research of Tomsk State University (2014-present).

His research interests are nonlinear and coherence optics, numerical simulation of optical properties of resonant absorbing and inhomogeneous media, fractal analysis, laser spectroscopy of biological probes.

O. Yu. Nikiforova graduated from Tomsk State University and received her Ph.D. degree in physics. She is currently a senior researcher in the Institute of Atmospheric Optics. The present work is related to the modeling of the absorption spectra of gaseous species, analysis of simulated and measured spectra, solution of inverse problems and, in particular, the use spectroscopic methods for medical diagnostics.

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Bulanova, A.A., Bukreeva, E.B., Kistenev, Y.V. et al. Diagnostics of bronchopulmonary diseases through Mahalanobis distance-based absorption spectral analysis of exhaled air. Front. Optoelectron. 8, 183–186 (2015). https://doi.org/10.1007/s12200-015-0498-7

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  • DOI: https://doi.org/10.1007/s12200-015-0498-7

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