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Recent progress in pediatric lymphoblastic leukemia

  • Progress in Hematology
  • Recent progress in pediatric leukemia
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

The probability of long-term survival for children with lymphoblastic leukemia has improved dramatically over recent decades, mainly owing to advances in genomic analysis techniques, which have improved our understanding of the nature of leukemic cells and prognostic prediction based on the evaluation of precise treatment response. Risk-adjusted chemotherapy based on these advances has simultaneously reduced relapse rates and minimized complications. In addition, recent genomic analyses have deepened our understanding of the pathogenesis of leukemia and revealed the involvement of germline variations in the clinical course of leukemia treatment. Additionally, advances in minimal residual disease assays and the introduction of immunotherapy are expected to further improve therapeutic analyses. Further advances in clinical and translational research are anticipated to improve survival to 100% in a healthy state.

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Data availability statement

Detailed data is available on request for the corresponding author.

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Acknowledgements

The author would like to thank Drs. Katsuyoshi Koh, Etsuko Yamazaki, and Fumihiko Hayakawa for constructive comments. We would like to thank Editage (http://www.editage.com) for English language editing. This work was supported in part by the AMED under Grant number JP22kk0305014, JP22ck0106759, JP22ck0106607, and JP22ck0106612.

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  1. Department of Pediatrics, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan

    Motohiro Kato

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MK: wrote the paper.

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Correspondence to Motohiro Kato.

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MK received honoraria from Amgen, Novartis, and Chugai and research funding from Otsuka.

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Kato, M. Recent progress in pediatric lymphoblastic leukemia. Int J Hematol 117, 155–161 (2023). https://doi.org/10.1007/s12185-022-03501-x

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