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Bilateral pulmonary nodules as a manifestation of primary pulmonary T-cell lymphoma

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Abstract

Primary pulmonary lymphoma (PPL) is an uncommon pathology and is usually of the B-cell type, originating in lymphoid tissue associated with the bronchial mucosa (MALT/BALT lymphoma). Very few cases of T-cell PPL, the majority diagnosed by open lung biopsy, have been described in medical literature. We report a case of an immunocompetent patient with fever and bilateral pulmonary nodules, diagnosed with T-cell PPL by transbronchial biopsy. The patient’s condition deteriorated and she responded poorly to chemotherapy. PPL should be included in the differential diagnosis of patients with fever and bilateral pulmonary nodules.

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Abbreviations

PPL:

Primary pulmonary lymphoma

MALT/BALT:

Lymphoid tissue associated with the bronchial mucosa

RCP:

Polymerase chain reaction

LDH:

Lactate dehydrogenase

ALP:

Fraction alkaline phosphatase

Hb:

Hemoglobin

WBC:

White blood cells

ESR:

Erythrocyte sedimentation rate

ANA:

Antinuclear antibody

Anti-DNA:

Deoxyribonucleic acid antibody

Anti-MB:

Basal membrane antibody

ANCA:

Antineutrophil cytoplasmic antibody

RNP:

Antiribonucleoprotein antibody

Sm:

Smith antigen antibody

Ro:

Ro antibody

La:

La antibody

Scl-70:

Scleroderma antibody

Jo-1:

Histidyl-tRNA-synthase antibody

HIV:

Human immunodeficiency virus

CT:

Computed tomography

ADA:

Adenosine deaminase

FNAP:

Fine-needle aspiration punctures

AIDS:

Acquired immune deficiency syndrome

References

  1. Chilosi M, Zinzani PL, Poletti V. Lymphoproliferative lung disorders. Semin Respir Crit Care Med. 2005;26:490–501.

    Article  PubMed  Google Scholar 

  2. Cordier J, Chailleux E, Lauque D, et al. Primary pulmonary lymphomas: a clinical study of 70 cases in nonimmunocompromised patients. Chest. 1993;103:201–8.

    Article  CAS  PubMed  Google Scholar 

  3. Asano Y, Ohshima K, Yoshizawa S, et al. Modified CHOP in an aged patient with non-Hodgkin’s lymphoma and probable extensive pulmonary involvement. Int J Hematol. 1991;54:327–9.

    CAS  PubMed  Google Scholar 

  4. Maehara T, Kobayashi H, Kaneko K, et al. A case of T-cell lymphoma of the lung. Nihon Kyobu Shikkan Gakkai Zasshi. 1991;29:469–76.

    CAS  PubMed  Google Scholar 

  5. Boon ES, Graal MB, van Noord JA. Primary extranodal non-Hodgkin’s lymphoma of the lung presenting with bilateral patchy infiltrates dramatically improving after corticosteroid therapy. Chest. 1993;104:1292–3.

    Article  CAS  PubMed  Google Scholar 

  6. Maejima S, Kitano K, Ichikawa S, et al. T-cell non-Hodgkin’s lymphoma of the lung. Int Med. 1993;32:403–7.

    Article  CAS  Google Scholar 

  7. Fujihara T, Mori F, Kawano K, et al. A case of T-cell type malignant lymphoma of the lung. Nippon Kyobu Geka Gakkai Zasshi. 1993;41:258–61.

    CAS  PubMed  Google Scholar 

  8. Hanada N, Abe T, Katagiri M, et al. A case of T-cell lymphoma showing multiple nodular shadows and an elevated titer of human T-lymphotropic virus type I (HTLV-I) antibody. Nihon Kyobu Shikkan Gakkai Zasshi. 1993;31:231–4.

    CAS  PubMed  Google Scholar 

  9. Sasaki Y, Yamagishi F, Suzuki K, et al. Primary pulmonary malignant lymphoma of the T-cell type. Nihon Kyobu Shikkan Gakkai Zasshi. 1995;33:1454–8.

    CAS  PubMed  Google Scholar 

  10. Hanawa T, Chiba W, Fujimoto T, et al. T-cell lymphoma presenting as recurrent bilateral pulmonary infiltrates over five years. Nihon Kyobu Shikkan Gakkai Zasshi. 1996;34:363–8.

    CAS  PubMed  Google Scholar 

  11. Karakus S, Yalcin S, Guler N, et al. Angiocentric T-cell lymphoma of the lung mimicking metastatic carcinoma. Case report. J Exp Clin Cancer Res. 1998;17:371–3.

    CAS  PubMed  Google Scholar 

  12. Kawashima O, Sakata S, Kamiyoshihara M, et al. Primary pulmonary collision tumor including squamous cell carcinoma and T-cell lymphoma. Lung Cancer. 1999;23:67–70.

    Article  CAS  PubMed  Google Scholar 

  13. De Torres JP, Kenney L, Celli B. Primary T-cell pulmonary lymphoma. A case report and review of the literature. Arch Bronconeumol. 2002;38:596–8.

    Article  PubMed  Google Scholar 

  14. Laohaburanakit P, Hardin KA. NK/T-cell lymphoma of the lung: a case report and review of literature. Thorax. 2006;61:267–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Pathological Anatomy Service, Hospital General Universitario Morales Meseguer, Murcia, Spain

    Andrés Nieto Olivares

  2. Pneumology Service, Hospital General Universitario Morales Meseguer, C/Marques de los Vélez, s/n, 30008, Murcia, Spain

    Roberto Bernabeu Mora & Juan Miguel Sánchez Nieto

Authors
  1. Roberto Bernabeu Mora
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  2. Juan Miguel Sánchez Nieto
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  3. Andrés Nieto Olivares
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Correspondence to Roberto Bernabeu Mora.

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Bernabeu Mora, R., Sánchez Nieto, J.M. & Nieto Olivares, A. Bilateral pulmonary nodules as a manifestation of primary pulmonary T-cell lymphoma. Int J Hematol 90, 153–156 (2009). https://doi.org/10.1007/s12185-009-0372-8

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  • DOI: https://doi.org/10.1007/s12185-009-0372-8

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