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A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia

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Abstract

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report the case of a 44-year-old man with APL carrying a new complex variant translocation (15;22;17). Karyotypic analysis with G-banding of bone marrow cells revealed t(15;22;17) (q22;q11.2;q21). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals. RT-PCR analysis showed long-form PML/RARA fusion transcripts. A complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). This is the first report of a new three-way translocation of 22q11 involvement with APL.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Takayasu Kato, Akira Hangaishi, Motoshi Ichikawa, Toru Motokura, Tsuyoshi Takahashi & Mineo Kurokawa

Authors
  1. Takayasu Kato
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  2. Akira Hangaishi
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  3. Motoshi Ichikawa
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  4. Toru Motokura
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  5. Tsuyoshi Takahashi
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  6. Mineo Kurokawa
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Corresponding author

Correspondence to Mineo Kurokawa.

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T. Kato and A. Hangaishi have contributed equally to this work.

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Kato, T., Hangaishi, A., Ichikawa, M. et al. A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia. Int J Hematol 89, 204–208 (2009). https://doi.org/10.1007/s12185-008-0253-6

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  • DOI: https://doi.org/10.1007/s12185-008-0253-6

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