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Hodgkin’s lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations

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Abstract

We describe the previously unreported condition of Hodgkin’s lymphoma in a patient with Noonan syndrome caused by germ-line mutations (1507G > C, Gly503Arg) in exon 13 of the PTPN11 gene. PTPN11, encoding SHP-2, is the first identified gene for Noonan syndrome and also the first identified proto-oncogene that encodes a tyrosine phosphatase. This somatic mutation has ever been reported in juvenile myelomonocytic leukemia (JMML). Furthermore, the functional analysis of this mutant SHP-2 has shown it to have enhanced phosphatase activity. Mutational analysis of PTPN11 gene in cancer cells and understanding how SHP-2 contributes to oncogenesis will provide new insight into the pathogenesis of Hodgkin’s lymphoma.

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Acknowledgments

This research was supported by Grant CMRPG460061 and CMRPG32048 awarded by the Chang Gung Memorial Hospital, Taiwan.

Conflict of interest disclosure

The authors declare no competing financial interests.

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Authors and Affiliations

  1. Department of Pediatrics, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taoyuan, Taiwan

    Fu-Sung Lo & Min-Tzu Kuo

  2. Department of Pathology, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taoyuan, Taiwan

    Tseng-Tong Kuo

  3. Department of Radiology, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, Taoyuan, Taiwan

    Chao-Jan Wang

  4. Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chung Gung University College of Medicine, 5, Fu-Shing Street, Kweishan, Taoyuan, 333, Taiwan

    Ming-Chung Kuo

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  1. Fu-Sung Lo
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  2. Tseng-Tong Kuo
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  3. Chao-Jan Wang
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  4. Min-Tzu Kuo
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Correspondence to Ming-Chung Kuo.

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Lo, FS., Kuo, TT., Wang, CJ. et al. Hodgkin’s lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations. Int J Hematol 88, 287–290 (2008). https://doi.org/10.1007/s12185-008-0157-5

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  • DOI: https://doi.org/10.1007/s12185-008-0157-5

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