Abstract
At present, food industries are considering rapid and reliable methods for maintaining quality and safety of foods for complying with the demands of regulatory authorities. Novel sensing methods like nanosensors are being used as effective methods of sensing for various applications in the food industries. Extensive research has been carried out on the gold nanoparticles (AuNP) for nanosensing applications. The use of its unique properties such as aggregation, fluorescence quenching, broad absorption at surface plasmon band, and biocompatibility is finding its place ensuring food safety. They hold the key to replace the existing conventional method used for detection of contaminants, pesticides, heavy metals, adulterants and other contaminants which are major threat to safety of food. This review provides an insight about research on the development of AuNP-based nanosensors and nanobiosensors for various applications in food industry. In addition, regulatory concerns as well as challenges and opportunities related to adoption of nanosensors in the field of food safety have been briefly discussed.
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References
Bi J, Tian C, Zhang GL, Hao H, Hou HM (2020) Detection of histamine based on gold nanoparticles with dual sensor system of colorimetric and fluorescence. Foods, 9(3). 10.3390/foods9030316
Abedalwafa MA, Tang Z, Qiao Y, Mei Q, Yang G, Li Y, Wang L (2020) An aptasensor strip-based colorimetric determination method for kanamycin using cellulose acetate nanofibers decorated DNA–gold nanoparticle bioconjugates. Microchim Acta 187(6). https://doi.org/10.1007/s00604-020-04348-x
Addou S, Fethi F, Chikri M, Rrhioua A (2016) Detection of argan oil adulteration with olive oil using fluorescence spectroscopy and chemometrics tools. J Mater Environ Sci 7(8):2689–2698
Adhikari K (2012) Globalisation and development in India – an overview. SSRN Electron J. https://doi.org/10.2139/ssrn.1624252
Adley C (2014) Past, Present and future of sensors in food production. Foods 3(3):491–510. https://doi.org/10.3390/foods3030491
Akgönüllü S, Yavuz H, Denizli A (2020) SPR nanosensor based on molecularly imprinted polymer film with gold nanoparticles for sensitive detection of aflatoxin B1. Talanta 219(June):121219. https://doi.org/10.1016/j.talanta.2020.121219
Alamer S, Chinnappan R, Zourob M (2017) Development of rapid immuno-based nanosensors for the detection of pathogenic bacteria in poultry processing plants. Procedia Technol 27:23–26. https://doi.org/10.1016/j.protcy.2017.04.012
Ali MA, Eldin TAS, Moghazy GMEI, Tork IM, Omara II (2014) Original research article detection of E. coli O157: H7 in feed samples using gold nanoparticles sensor. Int J Curr Microbiol Appl Sci 3(6):697–708
Amendola V, Meneghetti M, Stener M, Guo Y, Chen S, Crespo P, García MA, Hernando A, Pengo P, Pasquato L (2014) Physico-chemical characteristics of gold nanoparticles. In Comprehensive Analytical Chemistry (Vol. 66). https://doi.org/10.1016/B978-0-444-63285-2.00003-1
Azeredo HMCd (2009) Nanocomposites for food packaging applications. Food Res Int 42(9):1240–1253. https://doi.org/10.1016/j.foodres.2009.03.019
Bai W, Zhu C, Liu J, Yan M, Yang S, Chen A (2015) Gold nanoparticle-based colorimetric aptasensor for rapid detection of six organophosphorous pesticides. Environ Toxicol Chem 34(10):2244–2249. https://doi.org/10.1002/etc.3088
Bhalla N, Jolly P, Formisano N, Estrela P (2016) Introduction to biosensors. Essays Biochem 60(1):1–8. https://doi.org/10.1042/EBC20150001
Bulbul G, Hayat A, Andreescu S (2015) Portable nanoparticle-based sensors for food safety assessment. Sensors (switzerland) 15(12):30736–30758. https://doi.org/10.3390/s151229826
Chang K, Wang S, Zhang H, Guo Q, Hu X, Lin Z, Sun H, Jiang M, Hu J (2017) Colorimetric detection of melamine in milk by using gold nanoparticles-based LSPR via optical fibers. PLoS ONE 12(5):1–12. https://doi.org/10.1371/journal.pone.0177131
Charm Sciences Inc. (2018) Antibiotic Tests - Charm Sciences. http://www.charm.com/products/test-and-kits/antibiotic-tests/[Accessed on 22/11/2020]
Clau M, Bahmann D, Schmidt S (2013) Detection of antibiotic residues in food – pitfalls and optimization of agar diffusion tests in comparison with commercial test kits. In Microbial Pathogens and strategies for combating them: science, technology and education (pp. 359–366). http://www.formatex.info/microbiology4/vol1/359-366.pdf
Copper is essential for good health in humans, animals and plants (n.d.) Retrieved August 30, 2020, from https://copperalliance.org.uk/benefits-copper/health/
Darbha GK, Ray A, Ray PC (2007) Gold Nanoparticle-based miniaturized detection of mercury in soil, water, and. ACS Nano 1(3):208–214
Das M, Shim KH, An SSA, Yi DK (2011) Review on gold nanoparticles and their applications. J Toxicol Environ 3(4):193–205. https://doi.org/10.1007/s13530-011-0109-y
Das R, Chaterjee B, Kapil A, Sharma TK (2020) Aptamer-NanoZyme mediated sensing platform for the rapid detection of Escherichia coli in fruit juice. Sensing and Bio-Sensing Research 27:100313. https://doi.org/10.1016/j.sbsr.2019.100313
Dervisevic M, Dervisevic E, Çevik E, Şenel M (2017) Novel electrochemical xanthine biosensor based on chitosan–polypyrrole–gold nanoparticles hybrid bio-nanocomposite platform. J Food Drug Anal 25(3):510–519. https://doi.org/10.1016/j.jfda.2016.12.005
Devi R, Yadav S, Pundir CS (2012) Amperometric determination of xanthine in fish meat by zinc oxide nanoparticle/chitosan/multiwalled carbon nanotube/polyaniline composite film bound xanthine oxidase. Analyst 137(3):754–759. https://doi.org/10.1039/c1an15838d
Dew TP, Day AJ, Morgan MRA (2005) Xanthine oxidase activity in vitro: effects of food extracts and components. J Agric Food Chem 53(16):6510–6515. https://doi.org/10.1021/jf050716j
Dewan N, Ahmed P, Chowdhury G, Pandit S, Dasgupta D (2016) Nanotechnology based biosensors and its application. J Pharm Innov 18(6)18–25 www.thepharmajournal.com
Dorostkar S, Hemmateenejad B (2013) Label-free colorimetric detection of picomolar amounts of hydrazine using a gold nanoparticle-based assay. Jiran Chem Soc 10(3):513–519. https://doi.org/10.1007/s13738-012-0186-0
Efenberger-Szmechtyk M, Nowak A, Kregiel D (2018) Implementation of chemometrics in quality evaluation of food and beverages. Crit Rev Food Sci Nutr 58:1747–1766. https://doi.org/10.1080/10408398.2016.1276883
El-Nour KMA, Salam ETA, Soliman HM, Orabi AS (2017) Gold nanoparticles as a direct and rapid sensor for sensitive analytical detection of biogenic amines. Nanoscale Res Lett 12(1). https://doi.org/10.1186/s11671-017-2014-z
Fadel TR, Farrell DF, Friedersdorf LE, Griep MH, Hoover MD, Meador MA, Meyyappan M (2016) Toward the responsible development and commercialization of sensor nanotechnologies. ACS Sensors 1(3):207–216. https://doi.org/10.1021/acssensors.5b00279
Fahimi-Kashani N, Hormozi-Nezhad MR (2016) Gold-nanoparticle-based colorimetric sensor array for discrimination of organophosphate pesticides. Anal Chem 88(16):8099–8106. https://doi.org/10.1021/acs.analchem.6b01616
Feng J, Shen Q, Wu J, Dai Z, Wang Y (2019) Naked-eyes detection of Shigella flexneri in food samples based on a novel gold nanoparticle-based colorimetric aptasensor. Food Control 98:333–341. https://doi.org/10.1016/j.foodcont.2018.11.048
He P, Shen L, Liu R, Luo Z, Li Z (2011) Direct detection of β-agonists by use of gold nanoparticle-based colorimetric assays. Anal Chem 83(18):6988–6995. https://doi.org/10.1021/ac200769f
Hendzel MR, Jamieson DM (1976) Determination of mercury in fish. Anal Chem 48(6):926–928. https://doi.org/10.1021/ac60370a016
Heo J, Hua SZ (2009) An overview of recent strategies in pathogen sensing. Sensors (Switzerland) 9(6):4483–4502. https://doi.org/10.3390/s90604483
Hilali M, Charrouf Z, Soulhi AEA, Hachimi L, Guillaume D (2007) Detection of argan oil adulteration using quantitative campesterol GC-analysis. J Am Oil Chem Soc 84(8):761–764. https://doi.org/10.1007/s11746-007-1084-y
Inetianbor JE, Yakubu JM, Ezeonu SC (2015) Effects of food additives and preservatives on man—a review research article effects of food additives and preservatives on man — a review. Asian J Sci Technol 6(2):1118–1135
Jans H, Huo Q (2012) Gold nanoparticle-enabled biological and chemical detection and analysis. Chem Soc Rev 41(7):2849–2866. https://doi.org/10.1039/c1cs15280g
Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182. https://doi.org/10.1093/bmb/ldg032
Kannan P, Guo L (2020) Nanosensors for food safety. In Nanosensors for Smart Cities. INC. https://doi.org/10.1016/b978-0-12-819870-4.00019-0
Khan KM, Krishna H, Majumder SK, Gupta PK (2015) Detection of urea adulteration in milk using near-infrared raman spectroscopy. Food Anal Methods 8(1):93–102. https://doi.org/10.1007/s12161-014-9873-z
Kong D, Liu L, Song S, Suryoprabowo S, Li A, Kuang H, Wang L, Xu C (2016) A gold nanoparticle-based semi-quantitative and quantitative ultrasensitive paper sensor for the detection of twenty mycotoxins. Nanoscale 8(9):5245–5253. https://doi.org/10.1039/c5nr09171c
Kumar P, Ramulu Lambadi P, Kumar Navani N (2015) Non-enzymatic detection of urea using unmodified gold nanoparticles based aptasensor. Biosens Bioelectron 72:340–347. https://doi.org/10.1016/j.bios.2015.05.029
Lin YW, Huang CC, Chang HT (2011) Gold nanoparticle probes for the detection of mercury, lead and copper ions. Analyst 136(5):863–871. https://doi.org/10.1039/c0an00652a
Maduraiveeran G, Ramaraj R (2017) Gold nanoparticle-based sensing platform of hydrazine, sulfite, and nitrite for food safety and environmental monitoring. Anal Sci Technol 8(1):1–10. https://doi.org/10.1186/s40543-017-0113-1
Ma Q, Gong N, Li Y et al (2015) Gold nanoparticles as dual functional sensor to detect E.coliDH5α as a model for gram-negative bacteria. J Chin Chem Soc 62:521–527. https://doi.org/10.1002/jccs.201400536
Mehrotra P (2016) Biosensors and their applications — a review. J Oral Biol Craniofac Res 6(2):153–159. https://doi.org/10.1016/j.jobcr.2015.12.002
Milk Antibiotic Rapid Test Kits - Bioeasy (n.d.) Retrieved August 30, 2020, from http://en.bioeasy.com.tr/food-safety/milk-antibiotic-test-kits/
Mo R, Wang X, Yuan Q, Yan X, Su T, Feng Y, Lv L, Zhou C, Hong P, Sun S, Wang Z, Li C (2018) Electrochemical determination of nitrite by au nanoparticle/graphene-chitosan modified electrode. Sensors (Switzerland) 18(7):1–12
Mocan T, Matea CT, Pop T, Mosteanu O, Buzoianu AD, Puia C, Iancu C, Mocan L (2017) Development of nanoparticle-based optical sensors for pathogenic bacterial detection. J Nanobiotechnology 15(1):1–14. https://doi.org/10.1186/s12951-017-0260-y
Mungroo NA, Neethirajan S (2014) Biosensors for the detection of antibiotics in poultry industry—a review. Biosensors 4(4):472–493. https://doi.org/10.3390/bios4040472
Murugaboopathi G, Parthasarathy V, Chellaram C, Anand TP, Vinurajkumar S (2013) Applications of biosensors in food industry. Biosci Biotechnol Res Asia 10(2):711–714. https://doi.org/10.13005/bbra/1185
Neethirajan S, Jayas DS, Sadistap S (2009) Carbon dioxide (CO 2) sensors for the agri-food industry—a review. Food Bioprocess Technol 2(2):115–121. https://doi.org/10.1007/s11947-008-0154-y
Neethirajan S, Jayas DS (2011) Nanotechnology for the food and bioprocessing industries. Food Bioprocess Technol 4(1):39–47. https://doi.org/10.1007/s11947-010-0328-2
NEOGEN (n.d.) Reveal® Q+ for DON |. Retrieved August 30, 2020, from https://www.neogen.com/en-gb/categories/mycotoxins/reveal-q-plus-don/
Peng J, Liu L, Xu L, Song S, Kuang H, Cui G, Xu C (2017) Gold nanoparticle-based paper sensor for ultrasensitive and multiple detection of 32 (fluoro)quinolones by one monoclonal antibody. Nano Res 10(1):108–120. https://doi.org/10.1007/s12274-016-1270-z
Perez-Lopez B, Merkoçi A (2011) Nanomaterials based biosensors for food analysis applications. Trends Food Sci Technol 22(11):625–639. https://doi.org/10.1016/j.tifs.2011.04.001
Pop-Bio (n.d.) Retrieved August 30, 2020, from https://pop-bio.com/product/porcinetrace-rapid-test-kit-raw-meat/?v=c86ee0d9d7ed
Raj V, Vijayan AN, Joseph K (2015) Cysteine capped gold nanoparticles for naked eye detection of E. coli bacteria in UTI patients. Sensing and Bio-Sensing Research 5:33–36. https://doi.org/10.1016/j.sbsr.2015.05.004
Ramezani M, Esmaelpourfarkhani M, Taghdisi SM, Abnous K, Alibolandi M (2020) Application of nanosensors for food safety. In Nanosensors for Smart Cities. INC. https://doi.org/10.1016/b978-0-12-819870-4.00021-9
RapidChek® Campylobacter Media (n.d.) Retrieved August 30, 2020, from https://www.romerlabs.com/shop/romer_us_en/rapidchek-r-campylobacter-media/
RC T, AR (2015) Heavy metals contamination in vegetables and its growing soil. Journal of Environmental Analytical Chemistry, 02(03). https://doi.org/10.4172/2380-2391.1000142
SAs (Sulfonamides) Lateral Flow Assay Kit-Elabscience (n.d.) Retrieved August 30, 2020, from https://www.elabscience.com/p-sas_(sulfonamides)_lateral_flow_assay_kit-41037.html
Senkbeil S, Lafleur JP, Jensen TG, Kutter JP (2012) Gold nanoparticle-based fluorescent sensor for the analysis of dithiocarbamate pesticides in water. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS, pp. 1423–1425
Shah A (2020) A novel electrochemical nanosensor for the simultaneous sensing of two toxic food dyes. ACS Omega 5(11):6187–6193. https://doi.org/10.1021/acsomega.0c00354
Sharma A, Matharu Z, Sumana G, Solanki PR, Kim CG, Malhotra BD (2010) Antibody immobilized cysteamine functionalized-gold nanoparticles for aflatoxin detection. Thin Solid Films 519(3):1213–1218. https://doi.org/10.1016/j.tsf.2010.08.071
Song KM, Cho M, Jo H, Min K, Jeon SH, Kim T, Han MS, Ku JK, Ban C (2011) Gold nanoparticle-based colorimetric detection of kanamycin using a DNA aptamer. Anal Biochem 415(2):175–181. https://doi.org/10.1016/j.ab.2011.04.007
Stephen IB, Chen BH (2016) Nanomaterial-based sensors for detection of foodborne bacterial pathogens and toxins as well as pork adulteration in meat products. J Food Drug Anal 24(1):15–28. https://doi.org/10.1016/j.jfda.2015.05.001
Sugunan A, Thanachayanont C, Dutta J, Hilborn JG (2005) Heavy-metal ion sensors using chitosan-capped gold nanoparticles. Sci Technol Adv 6(3–4 SPEC.ISS):335–340. https://doi.org/10.1016/j.stam.2005.03.007
von Burg R (1992) Toxicology update. J Appl Toxicol 12(4):301–303. https://doi.org/10.1002/jat.2550120416
Vally H, Misso NLA (2012) Adverse reactions to the sulphite additives. Gastroenterol Hepatol Bed Bench 5:16–23. https://doi.org/10.22037/ghfbb.v5i1.221
Wang F, Han Y, Wang S, Ye Z, Wei L, Xiao L (2019) Single-particle LRET aptasensor for the sensitive detection of aflatoxin B1 with upconversion nanoparticles. Anal Chem 91(18):11856–11863. https://doi.org/10.1021/acs.analchem.9b02599
Wang J, Yang B, Wang H et al (2015) Highly sensitive electrochemical determination of Sunset Yellow based on gold nanoparticles/graphene electrode. Anal Chim Acta 893:41–48. https://doi.org/10.1016/j.aca.2015.08.042
Wang W, Liu L, Song S, Xu L, Kuang H, Zhu J, Xu C (2016) Gold nanoparticle-based strip sensor for multiple detection of twelve Salmonella strains with a genus-specific lipopolysaccharide antibody基于菌属特异性抗体的金标试纸传感器同时检测12种沙门氏菌. Sci China Mater 59(8):665–674. https://doi.org/10.1007/s40843-016-5077-0
Wang Y, Alocilja EC (2015) Gold nanoparticle-labeled biosensor for rapid and sensitive detection of bacterial pathogens. J Biol Eng 9(1):1–7. https://doi.org/10.1186/s13036-015-0014-z
Wang Z, Wu X, Liu L et al (2020) Rapid and sensitive detection of diclazuril in chicken samples using a gold nanoparticle-based lateral-flow strip. Food Chem 312:126116. https://doi.org/10.1016/j.foodchem.2019.126116
Wibowo KM, Sahdan MZ, Ramli NI, Muslihati A, Rosni N, Tsen VH, Saim H, Ahmad SA, Sari Y, Mansor Z (2018) Detection of Escherichia coli bacteria in wastewater by using graphene as a sensing material. J Phys Conf Ser. 995(1). https://doi.org/10.1088/1742-6596/995/1/012063
Yan S, Lai X, Du G, Xiang Y (2018) Identification of aminoglycoside antibiotics in milk matrix with a colorimetric sensor array and pattern recognition methods. Anal Chim Acta 1034:153–160. https://doi.org/10.1016/j.aca.2018.06.004
Yang X, Luo N, Tan Z, Jia Z, Liao X (2017) A Fluorescence Probe for Tartrazine Detection in Foodstuff Samples Based on Fluorescence Resonance Energy Transfer. Food Anal Methods 10(5):1308–1316. https://doi.org/10.1007/s12161-016-0691-3
Yasmin J, Ahmed MR, Cho BK (2016) Biosensors and their Applications in Food Safety: A Review. Biosyst Eng 41(3):240–254. https://doi.org/10.5307/jbe.2016.41.3.240
Zeng Y, Zhu Z, Du D, Lin Y (2016) Nanomaterial-based electrochemical biosensors for food safety. J Electroanal Chem 781:147–154. https://doi.org/10.1016/j.jelechem.2016.10.030
Zhu T, Hu Y, Yang K et al (2018) A novel SERS nanoprobe based on the use of core-shell nanoparticles with embedded reporter molecule to detect E. coli O157:H7 with high sensitivity. Microchim Acta 185:1–9. https://doi.org/10.1007/s00604-017-2573-9
Zougagh M, Salghi R, Dhair S, Rios A (2011) Nanoparticle-based assay for the detection of virgin argan oil adulteration and its rapid quality evaluation. Anal Bioanal Chem 399(7):2395–2405. https://doi.org/10.1007/s00216-010-4628-1
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Sarushi Rastogi – Conceptualization—Lead, Data curation—Lead, Writing original draft—Lead Vinita Kumari – Conceptualization – Equal, Data curation—Equal, Writing original draft—Equal, Vasudha Sharma—Project administration—Equal, Writing original draft and editing – Equal, F. J Ahmad—Project administration—Lead.
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Sarushi Rastogi declares no conflict of interest. Vinita Kumari declares no conflict of interest. Vasudha Sharma declares no conflict of interest. F. J. Ahmad declares no conflict of interest.
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Rastogi, S., Kumari, V., Sharma, V. et al. Gold Nanoparticle-based Sensors in Food Safety Applications. Food Anal. Methods 15, 468–484 (2022). https://doi.org/10.1007/s12161-021-02131-z
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DOI: https://doi.org/10.1007/s12161-021-02131-z