Skip to main content
SpringerLink
Log in

Une ascite révélant un lymphome non hodgkinien de type B et une hépatite chronique virale B

Ascites revealing a non-Hodgkin lymphoma and chronic hepatitis B

  • Article Original / Original Article
  • Published:
Journal Africain d'Hépato-Gastroentérologie

Résumé

Les lymphomes hépatiques correspondent le plus souvent à des localisations secondaires de lymphomes hodgkiniens ou non hodgkiniens ganglionnaires ou extraganglionnaires, de type B ou T selon la classification OMS. Ainsi, l’atteinte hépatique « secondaire » définit le stade IV de la classification d’Ann Arbor. La symptomatologie clinique est variée. Une cytolyse et/ou une cholestase peuvent être notées. La biopsie hépatique avec examen immunohistochimique confirme le diagnostic. Le traitement est basé sur une polychimiothérapie. Nous rapportons l’observation d’un patient ayant une hépatite chronique virale B et une infiltration hépatique par un lymphome non hodgkinien de phénotype B découvertes dans l’exploration d’une ascite récente.

Abstract

Hepatic localization of non-Hodgkin lymphoma is generally secondary, B or T-cell lymphoma, according to the classification by the World Health Organization. The liver involvement in lymphoma corresponds to stage IV of the Ann Arbor staging classification. The symptomatology is varied. Cytolysis and/or cholestasis can occur. Liver biopsy associated with an immunohistochemistry study confirms the diagnosis. Treatment consists of a polychemotherapy. We report the case of a patient presenting an ascites, which revealed a non-Hodgkin lymphoma and chronic hepatitis B.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

OMS:

Organisation mondiale de la santé

PA:

paquet-année

GGT:

gamma-glutamyl transpeptidase

TP:

taux de prothrombine

VS:

vitesse de sédimentation

CRP:

protéine C réactive

VS:

vitesse de sédimentation

BK:

bacille de Koch

ADN:

acide désoxyribonucléique

VIH:

virus de l’immunodéficience humaine

LDH:

lactate-déshydrogénase

LNH-B:

Lymphome malin non hodgkinien de type B

CHOP:

adriamycine, cyclophosphamide, vincristine, prednisone

VHC:

virus de l’hépatite C

ALAT:

alanine-aminotransférase

PBF:

ponction-biopsie du foie

Références

  1. Aozasa K, Mishima K, Ohsawa M (1993) Primary malignant lymphoma of the liver. Leuk Lymphoma 10:353–357

    Article  PubMed  CAS  Google Scholar 

  2. Zafrani ES, Gaulard P (1993) Primary lymphoma of the liver. Liver 13:57–61

    PubMed  CAS  Google Scholar 

  3. Jaffe ES (1987) Malignant lymphomas: pathology of hepatic involvement. Semin Liver Dis 7:257–268

    Article  PubMed  CAS  Google Scholar 

  4. Kim H, Dorfman RF (1974) Morphological studies of 84 untreated patients subjected to laparotomy for the staging of non Hodgkin’s lymphomas. Cancer 33:657–674

    Article  PubMed  CAS  Google Scholar 

  5. Dargent JL, De Wolf-Peeters C (1998) Liver involvement by lymphoma: identification of a distinctive pattern on infiltration related to T-cell/histiocyte-rich B-cell lymphoma. Ann Diagn Pathol 2:363–369

    Article  PubMed  CAS  Google Scholar 

  6. Dogan A, Burke JS, Goteri G, et al (2003) Micronodular Tcell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. Am J Surg Pathol 27:903–911

    Article  PubMed  Google Scholar 

  7. Harris AC, Ben-Ezra JM, Contos MJ, Kornstein MJ (1996) Malignant lymphoma can present as hepatobiliary disease. Cancer 78:2011–2019

    Article  PubMed  CAS  Google Scholar 

  8. Matano S, Nakamura S, Annen Y, et al (1998) Primary hepatic lymphoma in a patient with chronic hepatitis B. Am J Gastroenterol 93:2301–2302

    Article  PubMed  CAS  Google Scholar 

  9. Ozaki S, Ogasahara K, Kosaka M, et al (1998) Hepatosplenic gamma delta T-cell lymphoma associated with hepatitis B virus infection. J Med Investig 44:215–217

    CAS  Google Scholar 

  10. Ascoli V, Lo Coco F, Artini M, et al (1998) Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol 109:600–609

    PubMed  CAS  Google Scholar 

  11. Bronowicki JP, Bineau C, Feugier P, et al (2003) Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French patients. Hepatology 37:781–787

    Article  PubMed  Google Scholar 

  12. Prabhu RM, Medeiros LJ, Kumar D, et al (1998) Primary hepatic low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) associated with primary biliary cirrhosis. Mod Pathol 11:404–410

    PubMed  CAS  Google Scholar 

  13. Cazals HD (2007) Lymphomes hépatiques. Hepato-Gastroenterology 14:287–294

    Google Scholar 

  14. Alastair DB (2007) Mac Sween’s Pathology of the liver. 5th ed

  15. Ferri C, Lacivita L, Caracciolo F, et al (1994) Non Hodgkin’s lymphoma: possible role of hepatitis C virus. JAMA 272:355–356

    Article  PubMed  CAS  Google Scholar 

  16. Kim JH, Bang YJ, Park BJ, et al (2002) Hepatitis B virus infection and B-cell non-Hodgkin’s lymphoma in a hepatitis B endemic area: a case-control study. Jpn J Cancer Res 93:471–477

    PubMed  CAS  Google Scholar 

  17. Kuniyoshi M, Nakamuta M, Sakai H, et al (2001) Prevalence of hepatitis B or C virus infections in patients with non Hodgkin’s lymphoma. J Gastroenterol Hepatol 16:215–219

    Article  PubMed  CAS  Google Scholar 

  18. Cucuianu A, Patiu M, Duma M, et al (1999) Hepatitis B and C virus infection in Romanian non Hodgkin’s lymphoma patients. Br J Haematol 107:353–356

    Article  PubMed  CAS  Google Scholar 

  19. Yood MU, Quesenberry CP, Guo D, et al (2007) Incidence of Non Hodgkin’s lymphoma among individuals with chronic hepatitis B virus infection. Hepatology 46:107–112

    Article  CAS  Google Scholar 

  20. De Vita S, Sacco C, Sansonno D, et al (1997) Characterization of overt B-cell lymphomas in patients with hepatitis C virus infection. Blood 90:776–782

    PubMed  Google Scholar 

  21. Simpson ND, Simpson PW, Ahmed AM, et al (2003) Prophylaxis against chemotherapy-induced reactivation of hepatitis B virus infection with lamivudine. J Clin Gastroenterol 37:68–71

    Article  PubMed  CAS  Google Scholar 

  22. Yeo W, Chan PKS, Zhong S, et al (2000) Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol 62:299–307

    Article  PubMed  CAS  Google Scholar 

  23. Lok AS, Liang RH, Chiu EK et al (1991) Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology 100:182–188

    PubMed  CAS  Google Scholar 

  24. Jazayeri MS, Basuni AA, Cooksley G, et al (2004) Hepatitis B virus genotypes core gene variability and ethnicity in the pacific region. J Hepatol 41:139–146

    Article  PubMed  CAS  Google Scholar 

  25. Locarnini S (2004) Molecular virology of hepatitis B virus. Sem Liver Dis 24(Suppl 1):3–10

    Article  CAS  Google Scholar 

  26. Yeo W, Johnson, PJ (2006) Diagnosis prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology 43:209–220

    Article  PubMed  CAS  Google Scholar 

  27. Lau GKK, Yiu HH, Fong DY, et al (2003) Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy. Gastroenterology 125:1742–1749

    Article  PubMed  CAS  Google Scholar 

  28. Lalazar G, Rund D, Shouval D (2007) Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol 136:699–712

    Article  PubMed  CAS  Google Scholar 

  29. Hui C, Cheung W, Zhang H, Au W (2006) Kinetiks and risk of de novo hepatitis B infection in HbS Ag-negative patients undergoing cytotoxic chemotherapy. Gastroenterology 131:59–68

    Article  PubMed  CAS  Google Scholar 

  30. EASL clinical practice guidelines: Management of chronic hepatitis B (2009). European Association For The Study Of The Liver. J Hepatol 50:227–242

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Menzah, 5, cité les Pyramides, avenue d’Afrique, D 12, 2072, Tunis, Tunisie

    L. Hamzaoui

  2. Service d’hépatogastroentérologie, hôpital Tahar-Maamouri, Nabeul, Tunisie

    L. Hamzaoui, N. Ben Mahmoud, A. Mzid, N. El Jeridi, K. Siai & M. M. Azzouz

  3. Service d’anatomopathologie, hôpital Tahar-Maamouri, Nabeul, Tunisie

    S. Chatti

Authors
  1. L. Hamzaoui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Ben Mahmoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Mzid
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. El Jeridi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Siai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Chatti
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. M. Azzouz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. Hamzaoui.

About this article

Cite this article

Hamzaoui, L., Mahmoud, N.B., Mzid, A. et al. Une ascite révélant un lymphome non hodgkinien de type B et une hépatite chronique virale B. J Afr Hepato Gastroenterol 5, 74–79 (2011). https://doi.org/10.1007/s12157-011-0251-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12157-011-0251-9

Mots clés

Keywords

Search

Navigation