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F-18 FDG uptake on positron emission tomography as a predictor for lymphovascular invasion in patients with lung adenocarcinoma

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Abstract

Purpose

To evaluate the contributory value of Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of lymphovascular tumor invasion in patients with lung adenocarcinoma.

Materials and methods

We evaluated F-18 FDG-PET/CT images in 84 patients with histopathologically proven lung adenocarcinoma (37 men and 47 women, age range 39–83 years, mean age 67.0 ± 8.9 years). The maximum standardized uptake values (SUVmax) of the carcinomas were measured from the PET images. The Mann–Whitney U test was conducted to compare the median SUVmax between the tumor groups with and without lymphovascular invasion. In the subgroup patients with no lymph-node metastasis, we also compared the median SUVmax between the tumor groups with and without lymphatic invasion.

Results

The tumors with lymphovascular invasion had a significantly (P < 0.0001) greater median SUVmax than those without invasion. In the subgroup patients with no lymph-node metastasis, the median SUVmax was higher in tumors with lymphatic invasion than those without (P = 0.0004). The sensitivity, specificity, and area under the receiver operating characteristic curve for the detection of tumors with lymphovascular invasion were 89, 75 %, and 0.82, respectively, with a cutoff SUVmax value of 2.32.

Conclusion

The SUVmax of lung adenocarcinoma is a potential imaging biomarker for predicting tumor lymphovascular invasion.

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Authors and Affiliations

  1. Departments of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan

    Yoshifumi Noda, Satoshi Goshima, Masayuki Kanematsu, Haruo Watanabe, Hiroshi Kawada, Nobuyuki Kawai & Hiromi Ono

  2. Departments of Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan

    Masayuki Kanematsu

  3. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Kyongtae T. Bae

Authors
  1. Yoshifumi Noda
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  2. Satoshi Goshima
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  3. Masayuki Kanematsu
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  4. Haruo Watanabe
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  5. Hiroshi Kawada
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  6. Nobuyuki Kawai
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  7. Hiromi Ono
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  8. Kyongtae T. Bae
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Correspondence to Satoshi Goshima.

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Noda, Y., Goshima, S., Kanematsu, M. et al. F-18 FDG uptake on positron emission tomography as a predictor for lymphovascular invasion in patients with lung adenocarcinoma. Ann Nucl Med 30, 11–17 (2016). https://doi.org/10.1007/s12149-015-1023-1

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  • DOI: https://doi.org/10.1007/s12149-015-1023-1

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