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89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases

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Abstract

Objective

Strontium-89 chloride (89Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body 89Sr distribution.

Methods

89Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 %) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 %) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with 99mTc-HMDP whole body planar and merged SPECT images and compared with 89Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on 99mTc-HMDP images as a reference, the hot spots on 89Sr bremsstrahlung images were divided into the same bone parts as 99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on 89Sr bremsstrahlung whole body planar images.

Results

A total of 195 bone metastatic lesions were detected in both 99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in 89Sr merged SPECT images (127 of 195; 66 %) was more frequent than in 89Sr whole body planar images (108 of 195; 56 %), based on metastatic bone lesions in 99mTc-HMDP whole body planar and merged SPECT images. A large intestinal 89Sr accumulation was detected in 5 of the 13 patients (38 %).

Conclusions

89Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body 89Sr distribution than planar imaging. Intestinal 89Sr accumulation due to 89Sr physiologic excretion was detected in feces for 4 days after tracer injection.

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Authors and Affiliations

  1. Department of Radiology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan

    Seiichiro Ota, Kaoru Kikukawa & Hiroshi Toyama

  2. Section of Radiology, Fujita Health University Hospital, Toyoake, Japan

    Masaki Uno, Masaki Kato & Masanobu Ishiguro

  3. Faculty of Radiological Technology, Fujita Health University School of Health Sciences, Toyoake, Japan

    Takahiro Natsume, Masanori Tadokoro & Takashi Ichihara

Authors
  1. Seiichiro Ota
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  2. Masaki Uno
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  3. Masaki Kato
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  4. Masanobu Ishiguro
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  5. Takahiro Natsume
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  6. Kaoru Kikukawa
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  7. Masanori Tadokoro
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  8. Takashi Ichihara
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  9. Hiroshi Toyama
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Correspondence to Seiichiro Ota.

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Ota, S., Uno, M., Kato, M. et al. 89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases. Ann Nucl Med 28, 112–119 (2014). https://doi.org/10.1007/s12149-013-0788-3

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  • DOI: https://doi.org/10.1007/s12149-013-0788-3

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