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Initial experience with 18F-fluoroethylcholine PET/CT in staging and monitoring therapy response of advanced renal cell carcinoma

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Abstract

Objective

The use of 18F-fluoroethylcholine (FEC) PET/CT in staging and monitoring therapy response of advanced renal cell carcinoma (RCC) was prospectively analysed.

Methods

Preliminary results of two patients with metastatic RCC who underwent tumour nephrectomy as well as FEC PET/CT before and 10 weeks after two cycles of tyrosine kinase inhibitor therapy are presented.

Results

All in all, 18 tumour lesions were detected by baseline PET/CT, of which 10 (56%) were positive in FEC PET and 17 (94%) visible on contrast-enhanced computed tomography (ceCT). Mainly, small lung metastases resulted in the lower detection rate of FEC PET compared with ceCT. In follow-up PET/CT of the first case, progressive disease (PD) occurred with increase in tumour diameters of all metastases but non-uniform metabolic response. In the second case, partial response (PR) was achieved with concordant results of PET and CT. These results were confirmed by further CT in the course of disease.

Conclusions

In this small sample more than half of the RCC metastases were evident in baseline FEC PET. Monitoring therapy, FEC PET showed heterogeneous results in the first case with PD and was consistent with ceCT in the second one displaying PR.

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Conflict of interest statement

There have been no conflicts of interest and ethical adherence. Authors contributing to this study have not received any funding.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Hospital of the JW Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

    Marcus Middendorp, Bruno Sauter & Frank Grünwald

  2. Department of Oncology, Hospital of the JW Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

    Luise Maute

  3. Department of Radiology, Hospital of the JW Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

    Thomas J. Vogl

Authors
  1. Marcus Middendorp
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  2. Luise Maute
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  3. Bruno Sauter
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  4. Thomas J. Vogl
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  5. Frank Grünwald
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Correspondence to Marcus Middendorp.

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Middendorp, M., Maute, L., Sauter, B. et al. Initial experience with 18F-fluoroethylcholine PET/CT in staging and monitoring therapy response of advanced renal cell carcinoma. Ann Nucl Med 24, 441–446 (2010). https://doi.org/10.1007/s12149-010-0375-9

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  • DOI: https://doi.org/10.1007/s12149-010-0375-9

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