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Melanotic Neuroectodermal Tumor of Infancy: A Case Image

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Abstract

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm that can be mistaken for malignancies due to its unfamiliarity among clinicians and aggressive clinical appearance. We herein contributed by reporting an additional case of MNTI characterized by an extensive extraoral protrusion in a 2-month-old infant. The lesion involved the anterior maxilla, cheek, and infraorbital region, resulting the displacement of the nose to the contralateral side, and measuring approximately 10 cm in size. Surgical resection of the lesion was performed. After a 6-month follow-up, the patient has shown no evidence of recurrence. The rapid growth and aggressive behavior of MNTI emphasize the importance of an early diagnosis and prompt intervention in order to achieve favorable outcomes.

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Fig. 1
Fig. 2

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Acknowledgements

The authors would like to thank Dr. Hugo Gonzalez, head of the pediatric surgery service at Hospital Dr. Domingo Luciani, for medical support. B.A.B.A. is a research fellow of Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; #302627/2022-7) and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ; E-26/201.289/2022), Brazil. J.A.A.A. is the recipient of a fellowship granted by FAPERJ (E-26/200.331/2024). Mrs. E. Greene provided English editing of the manuscript.

Funding

This study was partially supported by the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ - E-26/201.289/2022; E-26/200.331/2024), Brazil.

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Authors and Affiliations

  1. Hospital Dr. Domingo Luciani, Caracas, Venezuela

    Ricardo Monsalve, César Arias & Henrique Vélez

  2. Department of Oral Medicine, School of Dentistry, Universidad Central de Venezuela, Caracas, Venezuela

    Mariana Villarroel-Dorrego

  3. Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Cidade Universitária, Rio de Janeiro, RJ, CEP: 21.941-902, Brazil

    José Alcides Almeida de Arruda & Bruno Augusto Benevenuto de Andrade

Authors
  1. Ricardo Monsalve
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  2. César Arias
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  3. Henrique Vélez
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  4. Mariana Villarroel-Dorrego
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  5. José Alcides Almeida de Arruda
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  6. Bruno Augusto Benevenuto de Andrade
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Contributions

RM, CA, and HV participated in the patient’s treatment, while MV-D contributed to the case diagnosis. JAAA and BABA authored the main manuscript and prepared Figs. 1, 2. All authors critically reviewed the manuscript.

Corresponding author

Correspondence to José Alcides Almeida de Arruda.

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The authors have no conflicts of interest to declare.

Ethical Approval

Data were collected in accordance with the guidelines of the institutional Research Ethics Board.

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No identifier information is included in the case report, and the study meets the waiver criteria for the institutional review board of Universidad Central de Venezuela.

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The parents of the patient provided written informed consent for the collection of data and the publication of this case report, including accompanying images.

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Monsalve, R., Arias, C., Vélez, H. et al. Melanotic Neuroectodermal Tumor of Infancy: A Case Image. Head and Neck Pathol 18, 15 (2024). https://doi.org/10.1007/s12105-024-01619-4

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  • DOI: https://doi.org/10.1007/s12105-024-01619-4

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