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Health Related Quality of Life and its Predictors among Bengali Thalassemic Children Admitted to a Tertiary Care Hospital

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Abstract

Objective

To assess the quality of life among thalassemic children and to find out association of quality of life (QOL) with the socio-demographic factors, and clinico-therapeutic profile.

Methods

This cross sectional descriptive epidemiological study was conducted from July 2011 through June 2012 on 365 admitted thalassemic patients of 5 to 12 y of age in the Burdwan Medical College and Hospital. Parents of the children were interviewed using Paediatric Quality of Life Inventory 4.0 Generic Core Scale. Statistically significant variables in bivariate analysis were considered for correlation matrix where independent variables were found inter related. So, partial correlation was done and statistically significant variables in partial correlation were considered for linear regression.

Results

The mean age of 365 thalassemic children was 8.3 ± 2.4 y. Multiple linear regressions predicted that only 70.5 % variation of total summary score depended on duration since splenectomy (31.2 % variation), last pre transfusion Hb level (20.7 %), family history of thalassemia (17.3 %) and frequency of blood transfusions (1.3 %). After splenectomy, thalassemic children could lead a better quality of life upto 5 y only. The betterment of the quality of life needs maintaining pre transfusion Hb level above 7 g/dl. Previous experience of the disease among the family members enriches the awareness among them and helps them to take correct decisions timely about the child and that leads to better QOL.

Conclusions

More awareness regarding the maintenance of pre transfusion Hb level should be built up among parents and families where such disease has occurred for the first time.

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References

  1. Weatherall DJ, Clegg JB. The thalassemia syndromes. 4th ed. Oxford: Blackwell Scientific Publications; 2001.

    Book  Google Scholar 

  2. Yaish HM. Thalassemia. Available at http://www.emedicine.com/PED/topic2229.htm. Accessed 6 Aug 2007.

  3. Verma IC, Choudhry VP, Jain PK. Prevention of thalassemia: a necessity in India. Indian J Pediatr. 1992;59:649–54.

    Article  CAS  PubMed  Google Scholar 

  4. Forrest CB, Simpson L, Clancy C. Child health services research: challenges and opportunities. JAMA. 1997;277:1787–93.

    Article  CAS  PubMed  Google Scholar 

  5. Homer CJ, Kleinman LC, Goldman DA. Improving the quality of care for children in health systems. Health Serv Res. 1998;33:1091–109.

    PubMed Central  CAS  PubMed  Google Scholar 

  6. McGlynn EA, Halfon N, Leibowitz A. Assessing the quality of care for children: prospects under health reform. Arch Pediatr Adolesc Med. 1995;149:359–68.

    Article  CAS  PubMed  Google Scholar 

  7. Seid M, Varni JW, Segall D, Kurtin PS. Health-related quality of life as a predictor of pediatric healthcare costs: a two-year prospective cohort analysis. Health Qual Life Outcomes. 2004;2:48.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Ismail A, Campbell MJ, Ibrahim HM, Jones GL. Health related quality of life in Malaysian children with thalassemia. Health Qual Life Outcomes. 2006;4:39.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Pakbaz Z, Treadwell M, Yamashita R, Quirolo K, Foote D, Quill L, et al. Quality of life in patients with thalassemia intermedia compared to thalassemia major. Ann N Y Acad Sci. 2005;1054:460–1.

    Google Scholar 

  10. Shaligram D, Girimaji SC, Chaturvedi SK. Psychological problems and quality of life in children with thalassemia. Indian J Pediatr. 2007;74:727–30.

    Article  CAS  PubMed  Google Scholar 

  11. Sachdeva A, Yadav SP, Berry AM, Kaul D, Khanna VK. Assessment of quality of life in thalassemia major. Int J Hematol. 2002;76:4–76.

    Google Scholar 

  12. Varni JW. The PedsQL™ measurement model for the pediatric quality of life inventory™. Available at http://www.pedsql.org/index.html. Accessed 28 May 2013 at 11p.m.

  13. El Dakhakhny AM, Hesham MA, Mohamed SE, Mohammad FN. Quality of life of school age thalassemic children at Zagazig city. J Am Sci. 2011;7:186–97.

    Google Scholar 

  14. Torcharus K, Pankaew T. Health-related quality of life in thalassemia treated with iron chelation. Royal Thai Army Med J. 2011;64:3–10.

  15. Thavorncharoensap M, Torcharus K, Nuchprayoon I, Riewpaiboon A, Indaratna K, Ubol B. Factors affecting health-related quality of life in Thai children with thalassemia. BMC Blood Disord. 2010;10:1–10.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Hussain S, Anwer A, Ahmad A, Jaffery S. Improved quality of life in post splenectomized thalassemic patients. Pak J Surg. 2011;27:83–6.

  17. Singer DB. Post-splenectomy sepsis. Perspect Paediatr Pathol. 1973;1:285–331.

    CAS  Google Scholar 

  18. Surapolchai P, Satayasai W, Sinlapamongkolkul P, Udomsubpayakul U. Biopsychosocial predictors of health-related quality of life in children with thalassemia in Thammasat University Hospital. J Med Assoc Thail. 2010;93:S65–75.

    Google Scholar 

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Contributions

RS: Primary researcher, planner, analysis of data and writing of article; RM: Guidance during article writing and will act as guarantor for this paper; IS: Guidance during article writing, statistical analysis.

Conflict of Interest

None.

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Authors and Affiliations

  1. Department of Community Medicine, Bankura Sammilani Medical College and Hospital, Bankura, West Bengal, India

    Rajib Saha

  2. Department of Community Medicine, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital (IPGME&R and SSKM Hospital), Kolkata, West Bengal, India

    Raghunath Misra

  3. Department of Community Medicine, IQ City Medical College and Narayana Hrudayalaya Hospitals, Durgapur, West Bengal, India

    Indranil Saha

  4. AD-234, Rabindrapally, Krishnapur, Kolkata, 700101, West Bengal, India

    Rajib Saha

Authors
  1. Rajib Saha
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  2. Raghunath Misra
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  3. Indranil Saha
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Corresponding author

Correspondence to Rajib Saha.

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Saha, R., Misra, R. & Saha, I. Health Related Quality of Life and its Predictors among Bengali Thalassemic Children Admitted to a Tertiary Care Hospital. Indian J Pediatr 82, 909–916 (2015). https://doi.org/10.1007/s12098-014-1670-6

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  • DOI: https://doi.org/10.1007/s12098-014-1670-6

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