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Mean Platelet Volume and Uric Acid Levels in Neonatal Sepsis

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Abstract

Objectives

To determine the role of mean platelet volume (MPV) and uric acid levels in the diagnosis of neonatal sepsis (NS).

Methods

A total of 146 newborns with suspected NS were prospectively included in the study and infants without NS (n = 142) were assigned as controls. The patients were divided into three groups: Group I (n = 64): clinical NS, Group II (n = 82): culture-proven NS, and Group III (n = 142): healthy controls.

Results

The patients in Group II had the highest C-reactive protein (CRP) levels (54.6 ± 5.4 mg/L), lowest platelet counts (199,329 ± 135,952/mm3) and lowest uric acid levels (2.6 ± 1.8 mg/dL) when compared to Groups I and III (p < 0.05, for all comparisons). MPV values were higher in Group I (10.6 ± 1.1 fL) and Group II (10.4 ± 0.9 fL) when compared to Group III (9.2 ± 1.2 fL) (p = 0.001), although there was no difference between Groups I and II. Area under curve (AUC) values for CRP, MPV, and uric acid were 0.92 (p = 0.001), 0.76 (p = 0.001) and 0.28 (p = 0.001), respectively. The diagnostic cut-off values for CRP and MPV were 9.5 mg/dL and 10.4 fL. Sensitivity and specificity of MPV in NS were 54 % and 82 % respectively. When combined with CRP its sensitivity and specificity increased to 89 % and 79 % respectively.

Conclusions

The combined use of CRP and MPV should be considered in the early diagnosis of NS, but uric acid levels may only be utilized as an additional tool to support diagnosis. CRP is shown to be more sensitive and specific than MPV and uric acid in diagnosing neonatal sepsis.

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Contributions

BA, DD, AZ: Concept and design, data analysis and interpretation, manuscript preparation, revision and final approval; NK, SB, NO; Concept and design, collection of data, manuscript preparation, revision and final approval. NO will act as guarantor for this paper.

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Authors and Affiliations

  1. Neonatal Intensive Care Unit, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey

    Banu Aydın, Dilek Dilli, Ayşegül Zenciroğlu, Nilgün Karadağ, Serdar Beken & Nurullah Okumuş

  2. Dr. Sami Ulus Hastanesi, Ankara, Turkey

    Serdar Beken

Authors
  1. Banu Aydın
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  2. Dilek Dilli
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  3. Ayşegül Zenciroğlu
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  4. Nilgün Karadağ
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  5. Serdar Beken
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  6. Nurullah Okumuş
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Correspondence to Serdar Beken.

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Aydın, B., Dilli, D., Zenciroğlu, A. et al. Mean Platelet Volume and Uric Acid Levels in Neonatal Sepsis. Indian J Pediatr 81, 1342–1346 (2014). https://doi.org/10.1007/s12098-014-1417-4

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  • DOI: https://doi.org/10.1007/s12098-014-1417-4

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