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Prooxidant-Antioxidant Balance in Perinatal Asphyxia

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Abstract

Objective

To determine the prooxidant-antioxidant balance (PAB) in neonatal asphyxia and compare it with values for PAB in healthy neonates.

Methods

In a prospective observational study, serum PAB of umbilical cord blood of 30 neonates with asphyxia [pH < 7.2, low Apgar score, signs of respiratory distress syndrome (RDS)] as the case group and 35 healthy neonates (without an abnormal clinical event at birth and after the first week) as the control group were compared.

Results

Among the 35 neonates in the control group, the average level of serum PAB was 20.00 HK units, which was significantly lower than for the 30 neonates within the case group (40.46 HK units; p = 0.019). The blood pH in the case group was significantly lower than for control group (P < 0.001). In controls, HCO3 - and pCO2 were 18.6 mmol/L and 38.5 mmHg respectively, whilst in the case group these values were 15.5 mmol/L and 45.7 mmHg respectively (p < 0.05).

Conclusions

Determination of PAB may be useful in the early diagnosis of perinatal asphyxia and is consistent with HCO3 -, pCO2 and Apgar score.

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Authors and Affiliations

  1. Neonatal Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hassan Boskabadi & Abbas Navaee Boroujeni

  2. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hesam Mostafavi-Toroghi, Golkoo Hosseini, Majid Ghayour-Mobarhan, Dariush Hamidi Alamdari & Hamidreza Saber

  3. Gynecology Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahtab Biranvandi

  4. Division of Medical Education, Brighton and Sussex Medical School, Brighton, UK

    Gordon A. Ferns

Authors
  1. Hassan Boskabadi
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  2. Abbas Navaee Boroujeni
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  3. Hesam Mostafavi-Toroghi
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  4. Golkoo Hosseini
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  5. Majid Ghayour-Mobarhan
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  6. Dariush Hamidi Alamdari
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  7. Mahtab Biranvandi
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  8. Hamidreza Saber
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  9. Gordon A. Ferns
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Corresponding author

Correspondence to Majid Ghayour-Mobarhan.

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Boskabadi, H., Navaee Boroujeni, A., Mostafavi-Toroghi, H. et al. Prooxidant-Antioxidant Balance in Perinatal Asphyxia. Indian J Pediatr 81, 248–253 (2014). https://doi.org/10.1007/s12098-013-1239-9

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  • DOI: https://doi.org/10.1007/s12098-013-1239-9

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