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The function of LncRNA-ATB in cancer

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Abstract

Cancer as a progressive and complex disease is caused by early chromosomal changes and stimulated cellular transformation. Previous studies reported that long non-coding RNAs (lncRNAs) play pivotal roles in the initiation, maintenance, and progression of cancer cells. LncRNA activated by TGF-β (ATB) has been shown to be dysregulated in different types of cancer. Aberrant expression of lncRNA-ATB plays an important role in the progression of diverse malignancies. High expression of LncRNA-ATB is associated with cancer cell growth, proliferation, metastasis, and EMT. LncRNA-ATB by targeting various signaling pathways and microRNAs (miRNAs) can trigger cancer pathogenesis. Therefore, lncRNA-ATB can be a novel target for cancer prediction and diagnosis. In this review, we will focus on the function of lncRNA-ATB in various types of human cancers.

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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Cheetham SW, Gruhl F, Mattick JS, Dinger ME. Long noncoding RNAs and the genetics of cancer. Br J Cancer. 2013;108:2419–25.

    Article  CAS  Google Scholar 

  2. Vervoort SJ, Devlin JR, Kwiatkowski N, Teng M, Gray NS, Johnstone RW. Targeting transcription cycles in cancer. Nat Rev Cancer. 2022;22:5–24.

    Article  CAS  Google Scholar 

  3. Gyamfi J, Kim J, Choi J. Cancer as a metabolic disorder. Int J Mol Sci. 2022;23:1155.

    Article  CAS  Google Scholar 

  4. Brandes N, Linial N, Linial M. Quantifying gene selection in cancer through protein functional alteration bias. Nucleic Acids Res. 2019;47:6642–55.

    Article  CAS  Google Scholar 

  5. Jiang J, Yuan J, Hu Z, Xu M, Zhang Y, Long M, Fan Y, Montone KT, Tanyi JL, Tavana O. Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets. Can Res. 2022;82:46–59.

    Article  CAS  Google Scholar 

  6. Jiang M-C, Ni J-J, Cui W-Y, Wang B-Y, Zhuo W. Emerging roles of lncRNA in cancer and therapeutic opportunities. Am J Cancer Res. 2019;9:1354–66.

    CAS  Google Scholar 

  7. Adnane S, Marino A, Leucci E. LncRNAs in human cancers: signal from noise. Trends in Cell Biol. 2022. https://doi.org/10.1016/j.tcb.2022.01.006.

    Article  Google Scholar 

  8. Zhang L, Ge X, Du J, Cheng X, Peng X, Hu J. Genome-wide identification of long non-coding RNAs and their potential functions in poplar growth and phenylalanine biosynthesis. Front Genet. 2021;12:762678.

    Article  CAS  Google Scholar 

  9. Ulitsky I. Interactions between short and long noncoding RNAs. FEBS Lett. 2018;592:2874–83.

    Article  CAS  Google Scholar 

  10. Noh JH, Kim KM, McClusky WG, Abdelmohsen K, Gorospe M. Cytoplasmic functions of long noncoding RNAs. Wiley Interdiscip Rev RNA. 2018;9: e1471.

    Article  Google Scholar 

  11. Statello L, Guo C-J, Chen L-L, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22:96–118.

    Article  CAS  Google Scholar 

  12. Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH. HiChIRP reveals RNA-associated chromosome conformation. Nat Methods. 2019;16:489–92.

    Article  CAS  Google Scholar 

  13. Yang M, Lu H, Liu J, Wu S, Kim P, Zhou X. lncRNAfunc: a knowledgebase of lncRNA function in human cancer. Nucleic Acids Res. 2022;50:D1295–306.

    Article  CAS  Google Scholar 

  14. Ramanathan M, Porter DF, Khavari PA. Methods to study RNA–protein interactions. Nat Methods. 2019;16:225–34.

    Article  CAS  Google Scholar 

  15. Rafiee A, Riazi-Rad F, Havaskary M, Nuri F. Long noncoding RNAs: regulation, function and cancer. Biotechnol Genet Eng Rev. 2018;34:153–80.

    Article  CAS  Google Scholar 

  16. Bukhari I, Khan MR, Hussain MA, Thorne RF, Yu Y, Zhang B, Zheng P, Mi Y. PINTology: a short history of the lncRNA LINC-PINT in different diseases. Wiley Interdiscip Rev RNA. 2022. https://doi.org/10.1002/wrna.1705.

    Article  Google Scholar 

  17. Garg M. Emerging roles of epithelial-mesenchymal plasticity in invasion-metastasis cascade and therapy resistance. Cancer Metastasis Rev. 2022;41(1):131–45.

    Article  Google Scholar 

  18. J. Graf, Functional characterization of the novel lncRNA LINC00941 in tissue homeostasis and disease in 2022.

  19. Yuan J-H, Yang F, Wang F, Ma J-Z, Guo Y-J, Tao Q-F, Liu F, Pan W, Wang T-T, Zhou C-C. A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 2014;25:666–81.

    Article  CAS  Google Scholar 

  20. Li J, Li Z, Zheng W, Li X, Wang Z, Cui Y, Jiang X. LncRNA-ATB: an indispensable cancer-related long noncoding RNA. Cell Prolif. 2017;50: e12381.

    Article  Google Scholar 

  21. Ying H, Wang Y, Gao Z, Zhang Q. Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells. Int Immunopharmacol. 2019;69:313–20.

    Article  CAS  Google Scholar 

  22. Xiao H, Zhang F, Zou Y, Li J, Liu Y, Huang W. The function and mechanism of long non-coding RNA-ATB in cancers. Front Physiol. 2018;9:321–321.

    Article  Google Scholar 

  23. Zhu H-Y, Bai W-D, Li C, Zheng Z, Guan H, Liu J-Q, Yang X-K, Han S-C, Gao J-X, Wang H-T. Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts. Sci Rep. 2016;6:1–9.

    Google Scholar 

  24. Wei L, Wu T, He P, Zhang J-L, Wu W. LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway. Oncol Lett. 2018;16:3907–12.

    Google Scholar 

  25. Li J, Li Z, Zheng W, Li X, Wang Z, Cui Y, Jiang X. Lnc RNA-ATB: an indispensable cancer-related long noncoding RNA. Cell Prolif. 2017;50: e12381.

    Article  Google Scholar 

  26. Saito T, Kurashige J, Nambara S, Komatsu H, Hirata H, Ueda M, Sakimura S, Uchi R, Takano Y, Shinden Y, Iguchi T, Eguchi H, Ehata S, Murakami K, Sugimachi K, Mimori K. A long non-coding RNA activated by transforming growth factor-β is an independent prognostic marker of gastric cancer. Ann Surg Oncol. 2015;22(3):S915-922.

    Article  Google Scholar 

  27. Bresesti C, Vezzoli V, Cangiano B, Bonomi M. Long non-coding RNAs: role in testicular cancers. Front Oncol. 2021;11:605606.

    Article  Google Scholar 

  28. Luo X, Tu T, Zhong Y, Xu S, Chen X, Chen L, Yang F. ceRNA network analysis shows that lncRNA CRNDE promotes progression of glioblastoma through sponge mir-9–5p. Front Genet. 2021;12:617350.

    Article  CAS  Google Scholar 

  29. Ala U. Competing endogenous RNAs non-coding RNAs and diseases: an intertwined story. Cells. 2020;9:1574.

    Article  CAS  Google Scholar 

  30. Shen X, Piao L, Zhang S, Cui Y, Cui Y, Quan X, Sun H. Long non-coding RNA activated by TGF-β expression in cancer prognosis: a meta-analysis. Int J Surg. 2018;58:37–45.

    Article  Google Scholar 

  31. Gao Z, Zhou H, Wang Y, Chen J, Ou Y. Regulatory effects of lncRNA ATB targeting miR-200c on proliferation and apoptosis of colorectal cancer cells. J Cell Biochem. 2020;121:332–43.

    Article  CAS  Google Scholar 

  32. Yang X, Tao H, Wang C, Chen W, Hua F, Qian H. lncRNA-ATB promotes stemness maintenance in colorectal cancer by regulating transcriptional activity of the β-catenin pathway. Exp Ther Med. 2020;19:3097–103.

    CAS  Google Scholar 

  33. Cao W, Peng T, Zhou Y. Long noncoding RNA activated by transforming growth factor-β promotes cancer development and is a prognostic marker in cervical cancer. J Cancer Res Ther. 2017;13:801.

    Article  CAS  Google Scholar 

  34. Xu S, Yi X-M, Tang C-P, Ge J-P, Zhang Z-Y, Zhou W-Q. Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncol Rep. 2016;36:10–22.

    Article  CAS  Google Scholar 

  35. Xiong J, Liu Y, Jiang L, Zeng Y, Tang W. High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma. Jpn J Clin Oncol. 2016;46:378–84.

    Article  Google Scholar 

  36. Huang D, Liu H, Li Z. Expression of lncRNA-ATB in laryngeal carcinoma and its relationship with prognosis. Eur Rev Med Pharmacol Sci. 2020;24:11148–53.

    Google Scholar 

  37. Cui W, Meng W, Zhao L, Cao H, Chi W, Wang B. TGF-β-induced long non-coding RNA MIR155HG promotes the progression and EMT of laryngeal squamous cell carcinoma by regulating the miR-155-5p/SOX10 axis. Int J Oncol. 2019;54:2005–18.

    CAS  Google Scholar 

  38. Li Z, Wu X, Gu L, Shen Q, Luo W, Deng C, Zhou Q, Chen X, Li Y, Lim Z. Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis. Cell Death Dis. 2017;8:e2888–e2888.

    Article  CAS  Google Scholar 

  39. Chen XJ, An N. Long noncoding RNA ATB promotes ovarian cancer tumorigenesis by mediating histone H3 lysine 27 trimethylation through binding to EZH2. J Cell Mol Med. 2021;25:37–46.

    Article  CAS  Google Scholar 

  40. Shoraka S, Mohebbi SR, Hosseini SM, Aghdaei HA, Zali MR. Identification of plasma lncRNA-ATB levels in hepatitis B virus-related cirrhosis and non-cirrhotic chronic hepatitis B patients. Virus Res. 2021;303: 198503.

    Article  CAS  Google Scholar 

  41. Dang X, Lian L, Wu D. The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritis. Cell Mol Biol Lett. 2018;23:1–9.

    Article  Google Scholar 

  42. Bian EB, Chen EF, Xu YD, Yang ZH, Tang F, Ma CC, Wang HL, Zhao B. Exosomal lncRNA-ATB activates astrocytes that promote glioma cell invasion. Int J Oncol. 2019;54:713–21.

    CAS  Google Scholar 

  43. Zheng X, Liu M, Song Y, Feng C. Long noncoding RNA-ATB impairs the function of tumor suppressor miR-126-mediated signals in endometrial cancer for tumor growth and metastasis. Cancer Biother Radiopharm. 2019;34:47–55.

    CAS  Google Scholar 

  44. Zhang Y, Li J, Jia S, Wang Y, Kang Y, Zhang W. Down-regulation of lncRNA-ATB inhibits epithelial–mesenchymal transition of breast cancer cells by increasing miR-141-3p expression. Biochem Cell Biol. 2019;97:193–200.

    Article  CAS  Google Scholar 

  45. Nikpayam E, Soudyab M, Tasharrofi B, Sarrafzadeh S, Iranpour M, Geranpayeh L, Mirfakhraie R, Gharesouran J, Ghafouri-Fard S. Expression analysis of long non-coding ATB and its putative target in breast cancer. Breast Dis. 2017;37:11–20.

    Article  CAS  Google Scholar 

  46. Qu S, Yang X, Song W, Sun W, Li X, Wang J, Zhong Y, Shang R, Ruan B, Zhang Z. Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer. Tumor Biol. 2016;37:3933–8.

    Article  CAS  Google Scholar 

  47. Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, Wang SB, Wang YZ, Yang Y, Yang N, Zhou WP, Yang GS, Sun SH. A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 2014;25:666–81.

    Article  CAS  Google Scholar 

  48. Li W, Kang Y. A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β. Cancer Cell. 2014;25:557–9.

    Article  CAS  Google Scholar 

  49. Sun T, Wong N. Transforming growth factor-β–induced long noncoding RNA promotes liver cancer metastasis via RNA–RNA crosstalk. Hepatology. 2015;61:722–4.

    Article  CAS  Google Scholar 

  50. Jang SY, Kim G, Park SY, Lee YR, Kwon SH, Kim HS, Yoon JS, Lee JS, Kweon Y-O, Ha HT. Clinical significance of lncRNA-ATB expression in human hepatocellular carcinoma. Oncotarget. 2017;8:78588.

    Article  Google Scholar 

  51. Fu N, Zhao S-X, Kong L-B, Du J-H, Ren W-G, Han F, Zhang Q-S, Li W-C, Cui P, Wang R-Q, Zhang Y-G, Nan Y-M. LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis. Gene. 2017;618:1–7.

    Article  CAS  Google Scholar 

  52. Lim SM, MohamadHanif EA, Chin SF. Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect. Cell Biosci. 2021;11:56.

    Article  CAS  Google Scholar 

  53. Wang D, He J, Huang B, Liu S, Zhu H, Xu T. Emerging role of the hippo pathway in autophagy. Cell Death Dis. 2020;11:880.

    Article  Google Scholar 

  54. Wang C-Z, Yan G-X, Dong D-S, Xin H, Liu Z-Y. LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma. World J Gastroenterol. 2019;25:5310–22.

    Article  CAS  Google Scholar 

  55. Chen W, Zhou S, Mao L, Zhang H, Sun D, Zhang J, Li J, Tang JH. Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis. Tumour Biol. 2016;37:10011–9.

    Article  CAS  Google Scholar 

  56. Yu Y, Luo W, Yang ZJ, Chi JR, Li YR, Ding Y, Ge J, Wang X, Cao XC. miR-190 suppresses breast cancer metastasis by regulation of TGF-β-induced epithelial-mesenchymal transition. Mol Cancer. 2018;17:70.

    Article  Google Scholar 

  57. Wu H-T, Zhong H-T, Li G-W, Shen J-X, Ye Q-Q, Zhang M-L, Liu J. Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer. J Transl Med. 2020;18:1–10.

    Article  CAS  Google Scholar 

  58. Liu L, Tong Q, Liu S, Cui J, Zhang Q, Sun W, Yang S. ZEB1 upregulates VEGF expression and stimulates angiogenesis in breast cancer. PLoS ONE. 2016;11: e0148774.

    Article  Google Scholar 

  59. Shi S-J, Wang L-J, Yu B, Li Y-H, Jin Y, Bai X-Z. LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. Oncotarget. 2015;6:11652.

    Article  Google Scholar 

  60. Li R-H, Chen M, Liu J, Shao C-C, Guo C-P, Wei X-L, Li Y-C, Huang W-H, Zhang G-J. Long noncoding RNA ATB promotes the epithelial− mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer. Cell Death Dis. 2018;9:1–16.

    Article  Google Scholar 

  61. El-Ashmawy NE, Hussien FZ, El-Feky OA, Hamouda SM, Al-Ashmawy GM. Serum LncRNA-ATB and FAM83H-AS1 as diagnostic/prognostic non-invasive biomarkers for breast cancer. Life Sci. 2020;259: 118193.

    Article  CAS  Google Scholar 

  62. Papoutsoglou P, Moustakas A. Long non-coding RNAs and TGF-β signaling in cancer. Cancer Sci. 2020;111:2672–81.

    Article  CAS  Google Scholar 

  63. Chen S, Shen X. Long noncoding RNAs: functions and mechanisms in colon cancer. Mol Cancer. 2020;19:167.

    Article  CAS  Google Scholar 

  64. Jia W, Zhou Y, Sun L, Liu J, Cheng Z, Zhao S. Potential effects of metformin on the vitality, invasion, and migration of human vascular smooth muscle cells via downregulating lncRNA-ATB. Dis Markers. 2022;2022:7480199.

    Article  Google Scholar 

  65. Yue B, Qiu S, Zhao S, Liu C, Zhang D, Yu F, Peng Z, Yan D. LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. J Gastroenterol Hepatol. 2016;31:595–603.

    Article  CAS  Google Scholar 

  66. Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H, Ueda M, Sakimura S, Takano Y, Kurashige J, Shinden Y, Eguchi H, Sugimachi K, Maehara Y, Mimori K. A long noncoding RNA, lncRNA-ATB is involved in the progression and prognosis of colorectal cancer. Anticancer Res. 2015;35:1385–8.

    CAS  Google Scholar 

  67. Liu X, Wang C. Long non-coding RNA ATB is associated with metastases and promotes cell invasion in colorectal cancer via sponging miR-141-3p. Exp Ther Med. 2020;20:1–1.

    Google Scholar 

  68. Abedini P, Fattahi A, Agah S, Talebi A, Beygi AH, Amini SM, Mirzaei A, Akbari A. Expression analysis of circulating plasma long noncoding RNAs in colorectal cancer: the relevance of lncRNAs ATB and CCAT1 as potential clinical hallmarks. J Cell Physiol. 2019;234:22028–33.

    Article  CAS  Google Scholar 

  69. Ti W, Wang J, Cheng Y. The interaction between long non-coding RNAs and cancer-associated fibroblasts in lung cancer. Front Cell Dev Biol. 2022;9:714125.

    Article  Google Scholar 

  70. Zhao W, Shan B, He D, Cheng Y, Li B, Zhang C, Duan C. Recent progress in characterizing long noncoding RNAs in cancer drug resistance. J Cancer. 2019;10:6693.

    Article  CAS  Google Scholar 

  71. Ginn L, Shi L, Montagna ML, Garofalo M. LncRNAs in non-small-cell lung cancer. Noncoding RNA. 2020;6:25.

    Article  CAS  Google Scholar 

  72. Zheng S, Lu Z, Liu C, Wang X, Jin R, Mao S, Huang J, Lei Y, Zhang C, Sun N, He J. The TGFβ-induced long non-coding RNA TBULC promotes the invasion and migration of non-small cell lung cancer cells and indicates poor prognosis. Front Oncol. 2019;9:1340–1340.

    Article  Google Scholar 

  73. Ke L, Xu SB, Wang J, Jiang XL, Xu MQ. High expression of long non-coding RNA ATB indicates a poor prognosis and regulates cell proliferation and metastasis in non-small cell lung cancer. Clin Transl Oncol. 2017;19:599–605.

    Article  CAS  Google Scholar 

  74. Lu G, Zhang Y. Long non-coding RNA ATB promotes human non-small cell lung cancer proliferation and metastasis by suppressing miR-141-3p. PLoS ONE. 2020;15: e0229118.

    Article  CAS  Google Scholar 

  75. Tang W, Yu X, Zeng R, Chen L. LncRNA-ATB promotes cisplatin resistance in lung adenocarcinoma cells by targeting the miR-200a/β-catenin pathway. Cancer Manag Res. 2020;12:2001.

    Article  CAS  Google Scholar 

  76. Gao Y, Wang J-W, Ren J-Y, Guo M, Guo C-W, Ning S-W, Yu S. Long noncoding RNAs in gastric cancer: from molecular dissection to clinical application. World J Gastroenterol. 2020;26:3401–12.

    Article  CAS  Google Scholar 

  77. Duan H, Ding X, Luo H. The prognostic value of long noncoding RNA activated by TGF-β in digestive system cancers: a meta-analysis. Medicine. 2020;99:e21324.

    Article  CAS  Google Scholar 

  78. Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, Tao Y, Shi W, Liu J. Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop. Biochem Biophys Res Commun. 2017;484:514–21.

    Article  CAS  Google Scholar 

  79. Milite C, Feoli A, Viviano M, Rescigno D, Cianciulli A, Balzano AL, Mai A, Castellano S, Sbardella G. The emerging role of lysine methyltransferase SETD8 in human diseases. Clin Epigenet. 2016;8:102–102.

    Article  Google Scholar 

  80. Nourbakhsh N, Emadi-Baygi M, Salehi R, Nikpour P. Gene expression analysis of two epithelial-mesenchymal transition-related genes: long noncoding RNA-ATB and SETD8 in gastric cancer tissues. Adv Biomed Res. 2018;7:42–42.

    Article  Google Scholar 

  81. Su M, Xiao Y, Ma J, Cao D, Zhou Y, Wang H, Liao Q, Wang W. Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications. J Hematol Oncol. 2018;11:118–118.

    Article  Google Scholar 

  82. Liu Q, Zheng S, Chen Y, Liu T, Han X, Zhang X, Shen T, Lu X. TGF-β1-induced upregulation of MALAT1 promotes kazakh’s esophageal squamous cell carcinoma invasion by EMT. J Cancer. 2020;11:6892.

    Article  CAS  Google Scholar 

  83. Mou K, Liu B, Ding M, Mu X, Han D, Zhou Y, Wang L-J. lncRNA-ATB functions as a competing endogenous RNA to promote YAP1 by sponging miR-590-5p in malignant melanoma. Int J Oncol. 2018;53:1094–104.

    CAS  Google Scholar 

  84. Lu R, Ji Z, Li X, Qin J, Cui G, Chen J, Zhai Q, Zhao C, Zhang W, Yu Z. Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2. Tumor Biol. 2015;36:6691–700.

    Article  CAS  Google Scholar 

  85. Han F, Wang C, Wang Y, Zhang L. Long noncoding RNA ATB promotes osteosarcoma cell proliferation, migration and invasion by suppressing miR-200s. Am J Cancer Res. 2017;7:770–83.

    CAS  Google Scholar 

  86. Ma C-C, Xiong Z, Zhu G-N, Wang C, Zong G, Wang H-L, Bian E-B, Zhao B. Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a. J Exp Clin Cancer Res. 2016;35:90.

    Article  Google Scholar 

  87. Lin H, Yang L, Tian F, Nie S, Zhou H, Liu J, Chen W. Up-regulated LncRNA-ATB regulates the growth and metastasis of cholangiocarcinoma via miR-200c signals. Onco Targets Ther. 2019;12:7561–71.

    Article  CAS  Google Scholar 

  88. Yuan D, Qian H, Guo T, Ye J, Jin C, Liu X, Jiang L, Wang X, Lin M, Yu H. LncRNA-ATB promotes the tumorigenesis of ovarian cancer via targeting miR-204-3p. Onco Targets Ther. 2020;13:573.

    Article  CAS  Google Scholar 

  89. Yuan D, Zhang X, Zhao Y, Qian H, Wang H, He C, Liu X, Guo T, Lin M, Yu H, Ye J. Role of lncRNA-ATB in ovarian cancer and its mechanisms of action. Exp Ther Med. 2020;19:965–71.

    CAS  Google Scholar 

  90. Zhu Y, Wu Y, Yang L, Dou X, Jiang J, Wang L. Long non-coding RNA activated by transforming growth factor-β promotes proliferation and invasion of cervical cancer cells by regulating the miR-144/ITGA6 axis. Exp Physiol. 2019;104:837–44.

    Article  CAS  Google Scholar 

  91. Xu W-W, Jin J, Wu X-y, Ren Q-L, Farzaneh M, MALAT1-related signaling pathways in colorectal cancer. Cancer Cell Int. 2022;22:1–9

    Article  CAS  Google Scholar 

  92. Farzaneh M, Kuchaki Z, Rashid Sheykhahmad F, Meybodi S M, Abbasi Y, Gholami E, Ghaedrahmati F, Anbiayee O, Emerging roles of JMJD3 in cancer. Clin Transl Oncol. 2022:1–12

  93. Fang Y, Zekiy A O, Ghaedrahmati F, Timoshin A, Farzaneh M, Anbiyaiee A, Khoshnam S.E, Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions. Cell Commun Signal 2021;19:1–8

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Amir Anbiyaiee

  2. Kerman University of Medical Sciences, University of Kerman, Kerman, Iran

    Mohammad Ramazii

  3. Department of Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran

    Siamak Soltani Bajestani

  4. Department of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Seyed Mohammadmahdi Meybodi

  5. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mona Keivan

  6. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Seyed Esmaeil Khoshnam

  7. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Farzaneh

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  1. Amir Anbiyaiee
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AA, MR, SSB, SMM, and MK: have made contributions to the writing of the manuscript. SEKH, and MF: have made substantial contribution to the revising of the manuscript. All authors have approved the submitted version of the article and have agreed to be personally accountable for the author’s own contributions and to ensure that questions related to the accuracy or integrity of any part of the work. All authors read and approved the final manuscript.

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Anbiyaiee, A., Ramazii, M., Bajestani, S.S. et al. The function of LncRNA-ATB in cancer. Clin Transl Oncol 25, 1–9 (2023). https://doi.org/10.1007/s12094-022-02848-1

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