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Bacterial driver–passenger model in biofilms: a new mechanism in the development of colorectal cancer

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Abstract

Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium and ranks the third largest diagnosed malignancy in the world. Many studies have shown that the high risk of CRC is believed to be related to the formation of biofilms. To prove causation, it will be significant to decipher which specific bacteria in biofilms initiate and maintain CRC and fully describe their underlying mechanisms. Here we introduce a bacterial driver–passenger model. This model added a novel and compelling angle to the role of microorganisms, putting more emphasis on the transformation of bacterial composition in biofilms which play different roles in the development of CRC. In this model, bacterial drivers can initiate the formation of CRC through genotoxicity, while bacterial passengers maintain the CRC process through metabolites. On the basis of these pathogens, we further turned our attention to strategies that can inhibit and eradicate these pathogenic biofilms, with the aim of finding new ways to hinder colorectal carcinogenesis.

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Funding

This study was supported by Training Project of Key Talents of Youth Medicine in Jiangsu province, China [No. QNRC2016330], The Key disease standardization diagnosis and treatment project in Jiangsu province [BE2015664], The Academic Science and Technology Innovation Fund for College Students [No. X20180714], the Social Development-Health Care Project of Yangzhou, Jiangsu Province [No. YZ2018087], the Social Development Project of Yangzhou, Jiangsu Province [No. YZ2021075], 2021 Jiangsu Graduate Research And Innovation Program (SJCX21 1644) and High-level talent “six one project” top talent scientific project of Jiangsu Province [No. LGY2019034].

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Authors and Affiliations

  1. Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China

    J. Xing, W. Zhang & H. Zhang

  2. Department of Clinical Medical College, Dalian Medical University, Dalian, Liaoning, People’s Republic of China

    Y. Fang

  3. Department of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu Province Hospital, Yangzhou University, Yangzhou, 225001, People’s Republic of China

    D. Tang & D. Wang

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  1. J. Xing
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  4. H. Zhang
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Contributions

JX and YF drafted the manuscript in detail. JX and HZ researched the literatures and drawn figures. YF, YC and WZ plotted the diagram and table. DT and DW critically revised the article for important intellectual content. JX and YF have contributed equally to this work and share first authorship. All authors have read and agreed to the published version of the manuscript.

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Correspondence to D. Tang.

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Xing, J., Fang, Y., Zhang, W. et al. Bacterial driver–passenger model in biofilms: a new mechanism in the development of colorectal cancer. Clin Transl Oncol 24, 784–795 (2022). https://doi.org/10.1007/s12094-021-02738-y

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