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Is lung resection appropriate for late octogenarians? Surgical outcomes of patients aged ≥ 80 years with lung cancer

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Abstract

Purpose

This study aimed to determine the outcomes and prognostic factors associated with octogenarians who underwent pulmonary resection for lung cancer.

Methods/patients

From 2009 to 2018, 76 octogenarians underwent pulmonary surgery for lung cancer at the Kanazawa Medical University, Japan. They were divided into two groups (early and late octogenarians), and their clinicopathological characteristics and outcomes were investigated. Overall survival rates and recurrence-free survival rates were determined using Kaplan–Meier curves. Univariate and multivariate analyses were performed to identify prognostic factors.

Results

Limited surgery was performed more often in the late octogenarian group; however, most perioperative factors were not significantly different between the two groups. The 3-year overall survival and recurrence-free survival rates were 61.2% and 52.8%, respectively. The median observation period was 37.5 (8.9–112.3) months postoperatively. Kaplan–Meier curves showed that age ≥ 85 years (late octogenarian), smoking history, and squamous cell carcinoma on histology were associated with worse survival rates. Multivariate analysis identified age ≥ 85 years (late octogenarian) (p = 0.011) and cigarette smoking (p = 0.025) as unfavorable prognostic factors for overall survival and recurrence-free survival, respectively.

Conclusions

Most octogenarians with an indication for surgery can tolerate pulmonary surgery. However, owing to the limitations of this retrospective, single-center study, future studies involving multiple-institutions are required to confirm our findings.

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Acknowledgements

We would like to express our gratitude to all the patients who participated in the study.

Funding

No funding was received for the study.

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan

    Y. Iijima, S. Iwai, A. Yamagata, N. Motono, K. Usuda & H. Uramoto

  2. Department of Thoracic Surgery, Aidu Chuo Hospital, Fukushima, Japan

    S. Yamagishi & K. Koizumi

Authors
  1. Y. Iijima
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  2. S. Iwai
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  3. A. Yamagata
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  4. N. Motono
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  5. K. Usuda
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  6. S. Yamagishi
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  7. K. Koizumi
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  8. H. Uramoto
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Contributions

Data analysis was performed by YI, the first draft of the manuscript was written by YI. All the authors contributed equally to the manuscript.

Corresponding author

Correspondence to Y. Iijima.

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Conflict of interest

All authors have no conflicts of interests to declare.

Ethics approval

Access and use of patient data were approved by the Kanazawa Medical University ethics committee (approval number: I160 and I449).

Consent to participate

Informed consent was obtained from the patients preoperatively and included access to their clinical records.

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All authors consent to the publication of the manuscript.

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Iijima, Y., Iwai, S., Yamagata, A. et al. Is lung resection appropriate for late octogenarians? Surgical outcomes of patients aged ≥ 80 years with lung cancer. Clin Transl Oncol 23, 1585–1592 (2021). https://doi.org/10.1007/s12094-021-02554-4

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  • DOI: https://doi.org/10.1007/s12094-021-02554-4

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