Abstract
Testicular cancer represents the most common malignancy in males aged 15–34 years. Nearly 40% of cases correspond to seminomas and three quarters of them are diagnosed with stage I disease. After orchiectomy, clinical staging should include serial tumour marker assays (alphafetoprotein must be negative), abdominal CT scan and chest X-ray films. Patients with stage I disease can be followed-up (active surveillance) or receive adjuvant carboplatin chemotherapy (those with rete testis invasion or non-compliant with follow-up). More advanced disease (stage II and III) and patients with extragonadal seminomas should receive chemotherapy (3–4 courses of BEP) according to IGCCCG risk classification. Residual lesions must be managed by surveillance if they are smaller than 3 cm, while those larger than 3 cm should be evaluated by means of PET. Surgery is only recommended in PET-positive lesions.
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Aparicio, J., Sastre, J., Germà, J.R. et al. SEOM clinical guidelines for diagnosis and treatment of testicular seminoma (2010). Clin Transl Oncol 13, 560–564 (2011). https://doi.org/10.1007/s12094-011-0697-7
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DOI: https://doi.org/10.1007/s12094-011-0697-7