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The matricellular protein CCN1 in tissue injury repair

Journal of Cell Communication and Signaling Aims and scope

Abstract

The expression of Ccn1 (Cyr61) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including fibrosis and cancer. Recent studies have found that CCN1 plays a critical role in promoting wound healing and tissue repair. Mechanistically, CCN1 functions through direct interaction with specific integrin receptors expressed in various cell types in the wound tissue microenvironment to coordinate diverse cellular functions for repair. Here we briefly summarize the current knowledge on the functions of CCN1 in tissue injury repair and discuss pertinent unanswered questions.

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Fig. 1: Schematic diagram of CCN1.
Fig. 2: CCN1 functions in wound healing.
Fig. 3: Parenchymal-specific CCN1 functions during the proliferation phase in repair.

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Acknowledgements

This work was supported by NIH grants R01AR061791, R01DK108994, and R01GM078492 to L.F.L.

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Correspondence to Lester F. Lau.

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Kim, KH., Won, J.H., Cheng, N. et al. The matricellular protein CCN1 in tissue injury repair. J. Cell Commun. Signal. 12, 273–279 (2018). https://doi.org/10.1007/s12079-018-0450-x

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