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Collision Tumour of Combined Neuroendocrine and Squamous Cell Carcinoma of Nasal Cavity and Paranasal Sinus- Case Report and Review of Literature

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Background

There have been many disputes about the definition, diagnosis, therapy, and prognosis of collision tumours.

Case Summary

We describe a rare patient with a collision tumour consisting of high-grade neuroendocrine carcinoma (NEC) and squamous cell carcinoma (SCC) in the right nasal cavity and paranasal sinus. She received surgery, concurrent chemoradiotherapy, and then two cycles of palliative chemotherapy. Follow-up at 26 months after diagnosis showed that this patient experienced a complete response with no signs of recurrence or metastasis. A literature review of previous 27 cases diagnosed with collision tumour of NEC and SCC in the head and neck was also undertaken.

Conclusion

It is highly challenging to manage collision tumours because these are two morphologically and etiologically distinct tumours. Well-designed multimodality therapy including surgery and chemoradiotherapy might lead to a long survival in these patients.

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Authors and Affiliations

  1. Department of Head and Neck Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, 110085, India

    Vikas Arora, Vishal Yadav, Manisha Aggarwal, Ghanashyam Mandal, Arnab Chakraborty & A K Dewan

  2. Department of Patho Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, 110085, India

    Meenakshi Kamboj

Authors
  1. Vikas Arora
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  2. Vishal Yadav
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  3. Manisha Aggarwal
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  4. Ghanashyam Mandal
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  5. Arnab Chakraborty
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  6. A K Dewan
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  7. Meenakshi Kamboj
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Correspondence to Manisha Aggarwal.

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Arora, V., Yadav, V., Aggarwal, M. et al. Collision Tumour of Combined Neuroendocrine and Squamous Cell Carcinoma of Nasal Cavity and Paranasal Sinus- Case Report and Review of Literature. Indian J Otolaryngol Head Neck Surg 75, 3765–3769 (2023). https://doi.org/10.1007/s12070-023-04101-9

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  • DOI: https://doi.org/10.1007/s12070-023-04101-9

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