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Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT

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Abstract

Granular cell tumor (GCT) is an uncommon benign neoplasm derived from Schwann cells, frequently affecting the oral cavity, skin, and gastrointestinal tract. On microscopy, pseudocarcinomatous squamous hyperplasia (PSH) and perineural involvement are potential diagnostic pitfalls. GCT should be differentiated from non-neural GCT (NN-GCT). A 13-year-old male patient was referred presenting a nodular lesion on the upper lip several months ago. After excisional biopsy, microscopy revealed GCT without PSH but presenting multifocal perineural involvement. By immunohistochemistry, ALK was negative, whereas Rb and INI1 expression was intact. Moreover, with few intraoral NN-GCTs being assessed, recent studies suggest that acquired dermal NN-GCT subgroup seems to correspond to ALK-rearranged variants of epithelioid fibrous histiocytoma. Accordingly, further research on this topic is strongly encouraged.

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Funding

Jorge Esquiche León has received research grants from National Council for Scientific and Technological Development (CNPq) (304241/2021-0) and State of São Paulo Research Foundation (FAPESP) (2016/11419-0, 2022/07479-9 and 2022/12760-9).

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Authors and Affiliations

  1. Department of Pediatric Dentistry – Riberão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil

    Julia Biliato Javaroni & Magdalena Raquel Torres Reyes

  2. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, SP, 14040-904, Brazil

    Heitor Albergoni Silveira & Jorge Esquiche León

  3. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil

    Jorge Esquiche León

  4. Department of Dentistry, Clinical Stomatology, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil

    Ana Terezinha Marques Mesquita & Gabriela Fonseca Rocha

Authors
  1. Julia Biliato Javaroni
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  2. Heitor Albergoni Silveira
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  3. Magdalena Raquel Torres Reyes
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  4. Ana Terezinha Marques Mesquita
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  5. Gabriela Fonseca Rocha
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  6. Jorge Esquiche León
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Correspondence to Jorge Esquiche León.

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Javaroni, J.B., Silveira, H.A., Reyes, M.R.T. et al. Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT. Indian J Otolaryngol Head Neck Surg 75, 3920–3924 (2023). https://doi.org/10.1007/s12070-023-03957-1

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  • DOI: https://doi.org/10.1007/s12070-023-03957-1

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