Skip to main content

Advertisement

Log in

Sinonasal Inverted Papilloma: A Narrative Review

  • Other Articles
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Inverted papilloma (IP) is a relatively rare sinonasal benign lesion, peculiar in its etiology, clinical presentation and treatment. Its resemblance to other sinonasal pathologies and varied approaches, makes it an interesting disease. Recently there have been several advances in the management of IP. This article aims to summarize the contemporary developments thus enabling the readers to understand the years of research behind IP. To integrate the available literature on IP and study the current scenario in its management. A comprehensive literature review was done on Google Scholar and PubMed database using the following key words: “inverted papilloma”, “Schneiderian”, “sinonasal”, “medial maxillectomy”. Articles published in English were used. Articles published till May 2020 were reviewed. Years of research have aimed to gain more information regarding the epidemiology, histopathology, staging systems and surgical management of IP. To briefly summarize the research so far, it is safe to say that there exists an association between Human Papilloma Virus and IP. The Krouse staging system is the most commonly used. The treatment itself has changed from a conservative approach to a more aggressive excision with or without external approach and with or without chemoradiotherapy. In IP, whether or not associated with SCC, complete surgical removal of the tumour is advocated as the treatment of choice. With the advancements in endoscopic technique, surgeons have been using it to their advantage for the surgical evaluation and cure of IP, depending upon the stage. Endoscopic treatment is preferred, whereas for lesions less accessible endoscopically, or in those with peripheral extension, open surgery is indicated. Every patient requires counselling before discharge and thorough examination during the follow-up to detect any evidence of recurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Moideen SP (2019) Inverted papilloma – clinical features, diagnosis and treatment

  2. Barnes L (2002) Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck. Mod Pathol 15(3):279–297. https://doi.org/10.1038/modpathol.3880524

    Article  PubMed  Google Scholar 

  3. Vorasubin N, Vira D, Suh JD, Bhuta S, Wang MB (2013) Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types. Am J Rhinol Allergy 27(4):287–292. https://doi.org/10.2500/ajra.2013.27.3904

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mohan S, Nair S, Sharma M, Nilakantan A, Malik A (2015) Inverted papilloma of frontal sinus with intracranial extension. Med J Armed Forces India 71(Suppl 1):S152–S155. https://doi.org/10.1016/j.mjafi.2013.10.009

    Article  PubMed  Google Scholar 

  5. Dunbar NE, Segrin C (2012) International scholarly research notices. ISRN Educ 2012:1–9. https://doi.org/10.5402/2012/982934

    Article  CAS  Google Scholar 

  6. Xu B, Magliocca K, Zynger D (2020) Nasal cavity, paranasal sinuses, nasopharynx benign/nonneoplastic lesions: epithelial sinonasal papilloma

  7. But-Hadzic J, Jenko K, Poljak M, Kocjan B, Gale N, Strojan P (2011) Sinonasal inverted papilloma associated with squamous cell carcinoma. Radiol Oncol 45(4):267–272. https://doi.org/10.2478/v10019-011-0033-4

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wieneke JA, Koeller KK (2020) Head neck pathol radiology pathology classics. Head Neck Pathol 1(2):99–101. https://doi.org/10.1007/s12105-007-0019-0

    Article  Google Scholar 

  9. Ungari C (2015) Management and treatment of sinonasal inverted papilloma. Ann Stomatol (Roma) 6:87–90. https://doi.org/10.11138/ads/2015.6.3.087

    Article  PubMed  Google Scholar 

  10. Wang M-J, Noel JE (2017) Etiology of sinonasal inverted papilloma: a narrative review. World J Otorhinolaryngol Head Neck Surg 3(1):54–58. https://doi.org/10.1016/j.wjorl.2016.11.004

    Article  PubMed  Google Scholar 

  11. Budu V, Schnaider A, Bulescu I (2015) Endoscopic approach of sinonasal inverted papilloma—our 15 years’ experience on 162 cases. Rom J Rhinol 5(17):31–36. https://doi.org/10.1515/rjr-2015-0004

    Article  Google Scholar 

  12. Syrjänen KJ (2003) HPV infections in benign and malignant sinonasal lesions. J Clin Pathol 56(3):174–181. https://doi.org/10.1136/jcp.56.3.174

    Article  PubMed  PubMed Central  Google Scholar 

  13. Gaudio JD (2010) Smoking increases risk of inverted papilloma recurrence

  14. Liang QZ, Li DZ, Wang XL, Huang H, Xu ZG, Wu YH (2015) Survival outcome of squamous cell carcinoma arising from sinonasal inverted papilloma. Chin Med J (Engl) 128(18):2457–2461. https://doi.org/10.4103/0366-6999.164929

    Article  PubMed  Google Scholar 

  15. Khandekar S, Dive A, Mishra R, Upadhyaya N (2015) Sinonasal inverted papilloma: a case report and mini review of histopathological features. J Oral Maxillofac Pathol 19(3):405. https://doi.org/10.4103/0973-029x.174644

    Article  PubMed  PubMed Central  Google Scholar 

  16. Dammann F, Pereira P, Laniado M, Plinkert P, Löwenheim H, Claussen CD (1999) Inverted papilloma of the nasal cavity and the paranasal sinuses: using CT for primary diagnosis and follow-up. Am J Roentgenol 172(2):543–548. https://doi.org/10.2214/ajr.172.2.9930821

    Article  CAS  Google Scholar 

  17. Bugter O, Monserez DA, Van Zijl FVWJ, Baatenburg De Jong RJ, Hardillo JA (2017) Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up. J Otolaryngol Head Neck Surg 46(1):1–13. https://doi.org/10.1186/s40463-017-0246-7

    Article  Google Scholar 

  18. Díaz Molina JP, Llorente Pendas JL et al (2009) Inverted sinonasal papillomas. Review of 61 cases. Acta Otorrinolaringológica Española 60(6):402–408. https://doi.org/10.1016/S2173-5735(09)70166-8

    Article  PubMed  Google Scholar 

  19. Karkos PD, Khoo LC, Leong SC (2020) Computed tomography and/or magnetic resonance imaging for pre- operative planning for inverted nasal papilloma: review of evidence. J Laryngol Otol 123(7):1–4

    Google Scholar 

  20. Di Muzio B, Gaillard F et al (2020) Inverted papilloma. https://radiopaedia.org/articles/invertedpapilloma

  21. Yousuf K, Wright ED (2007) Site of attachment of inverted papilloma predicted by CT findings of osteitis. Am J Rhinol 21(1):32–36. https://doi.org/10.2500/ajr.2007.21.2984

    Article  PubMed  Google Scholar 

  22. Ojiri H, Shimpe MU, Fukuda TK (2000) Potentially distinctive features of sinonasal inverted papilloma on MR imaging. Am J Roentgenol 175(2):465–468. https://doi.org/10.2214/ajr.175.2.1750465

    Article  CAS  Google Scholar 

  23. (2020) The role of endoscopic surgery in the treatment of nasal inverted papilloma. Revista Brasileira de Otorrinolaringologia. ISSN 0034-7299

  24. Pagella F et al (2017) ‘TuNa-saving’ endoscopic medial maxillectomy: a surgical technique for maxillary inverted papilloma. Eur Arch Oto-Rhino-Laryngol 274(7):2785–2791. https://doi.org/10.1007/s00405-017-4549-0

    Article  Google Scholar 

  25. Krouse JH (2000) Development of a staging system for inverted papilloma. Laryngoscope 110(6):965–968. https://doi.org/10.1097/00005537-200006000-00015

    Article  CAS  PubMed  Google Scholar 

  26. Gras-Cabrerizo JR, Montserrat-Gili JR, Massegur-Solench H, León-Vintró X, De Juan J, Fabra-Llopis JM (2010) Management of sinonasal inverted papillomas and comparison of classification staging systems. Am J Rhinol Allergy 24(1):66–69. https://doi.org/10.2500/ajra.2010.24.3421

    Article  PubMed  Google Scholar 

  27. Boyd B, Boyd JT (2011) Case reports in otolaryngology. Case Rep Otolaryngol 2013:2

    Google Scholar 

  28. Durucu C, Baglam T, Karatas E, Mumbuc S, Kanlikama M (2009) Surgical treatment of inverted papilloma. J Craniofac Surg 20(6):1985–1988. https://doi.org/10.1097/SCS.0b013e3181bd2dc4

    Article  PubMed  Google Scholar 

  29. de Ferreira LMBM, do Nascimento Rios AS, Gomes ÉF, Azevedo JF, de Paula Araújo R, Moraes RB (2006) Midfacial degloving—acess to nasal cavity and paranasal sinuses lesions. Braz J Otorhinolaryngol 72(2):158–162. https://doi.org/10.1016/s1808-8694(15)30050-1

    Article  PubMed  Google Scholar 

  30. Cheung FMF, Lau TWS, Cheung LKN, Li ASM, Chow SK, Lo AWI (2010) Schneiderian papillomas and carcinomas: a retrospective study with special reference to p53 and p16 tumor suppressor gene expression and association with HPV. Ear Nose Throat J. https://doi.org/10.1177/014556131008901002

    Article  PubMed  Google Scholar 

  31. Lisan Q, Moya-Plana A, Bonfils P (2017) Association of Krouse classification for sinonasal inverted papilloma with recurrence: a systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg 143(11):1104–1110. https://doi.org/10.1001/jamaoto.2017.1686

    Article  PubMed  PubMed Central  Google Scholar 

  32. Li L, Zhao G, Shi Z, Qi L, Zhou L, Fu Z (2016) Oncology letters. Oncol Lett 12(5):3045–3050

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Kamath MP, Shenoy SV, Prasad V, Bhojwani K, Pai R, Mathew NM (2015) Inverted papilloma of atypical origin with unusual extension into the oropharynx. J Cancer Res Ther 11(3):666. https://doi.org/10.4103/0973-1482.140830

    Article  PubMed  Google Scholar 

  34. Garcia AS, Bravo-Calderón DM, Ferreira MP, Oliveira DT (2014) Squamous cell carcinoma arising from inverted schneiderian papilloma: a case report with oral involvement. Case Rep Otolaryngol 2014:1–3. https://doi.org/10.1155/2014/478092

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kartika Rao.

Ethics declarations

Conflict of interest

The authors declare no conflict of interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Upadhya, I.B., Rao, K. Sinonasal Inverted Papilloma: A Narrative Review. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 1017–1022 (2022). https://doi.org/10.1007/s12070-020-02089-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-020-02089-0

Keywords

Navigation