Abstract
Infective endocarditis involving the aortic root is associated with a high degree of morbidity and mortality. Native aortic root infections can develop from aggressive organisms or from delays in diagnosis or definitive care, whereas prosthetic valve infections commonly result in extensive destruction of the aortic root and neighboring structures. Early detection, tailored antibiotic therapy, thoughtful pre-operative planning, and multidisciplinary heart team management are the keys to optimizing patient outcomes. Aggressive and complete surgical debridement are mandatory prior to aortic root reconstruction. Surgical experience and patient-centered decision making are critical in selecting the optimal reconstructive strategy for the aortic root and adjacent structures.
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References
Rajani R, Klein JL. Infective endocarditis: a contemporary update. Clin Med. 2020;20:31.
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC Guidelines for the management of infective endocarditis. Kardiologia Polska (Polish Heart Journal). 2015;73:963–1027.
Writing Committee Members, Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin III JP, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77:e25–197.
Yang A, Tan C, Daneman N, Hansen MS, Habib G, Salaun E, et al. Clinical and echocardiographic predictors of embolism in infective endocarditis: systematic review and meta-analysis. Clin Microbiol Infect. 2019;25:178–87.
Mahmoud K, Hammouda T, Kandil H, Mashaal M. Prevalence and predictors of aortic root abscess among patients with left-sided infective endocarditis: a cross-sectional comparative study. Egypt Heart J. 2020;72:1–9.
Ergin MA, Raissi S, Follis F, Lansman SL, Griepp RB. Annular destruction in acute bacterial endocarditis: surgical techniques to meet the challenge. J Thorac Cardiovasc Surg. 1989;97:755–63.
Watanabe G, Haverich A, Speier R, Dresler C, Borst HG. Surgical treatment of active infective endocarditis with paravalvular involvement. J Thorac Cardiovasc Surg. 1994;107:171–7.
Chan KL. Early clinical course and long-term outcome of patients with infective endocarditis complicated by perivalvular abscess. CMAJ. 2002;167:19–24.
Cuervo G, Escrihuela-Vidal F, Gudiol C, Carratalà J. Current challenges in the management of infective endocarditis. Front Med. 2021;8:641243.
Omari B, Shapiro S, Ginzton L, Robertson JM, Ward J, Nelson RJ, Bayer AS. Predictive risk factors for periannular extension of native valve endocarditis: clinical and echocardiographic analyses. Chest. 1989;96:1273–9.
Piper C, Hetzer R, Körfer R, Bergemann R, Horstkotte D. The importance of secondary mitral valve involvement in primary aortic valve endocarditis. The mitral kissing vegetation. Eur Heart J. 2002;23:79–86.
San Román JA, Vilacosta I, Sarriá C, de la Fuente L, Sanz O, Vega JL, et al. Clinical course, microbiologic profile, and diagnosis of periannular complications in prosthetic valve endocarditis. Am J Cardiol. 1999;83:1075–9.
Leontyev S, Borger MA, Modi P, Lehmann S, Seeburger J, Doenst T, et al. Surgical management of aortic root abscess: a 13-year experience in 172 patients with 100% follow-up. J Thorac Cardiovasc Surg. 2012;143:332–7.
DiNubile MJ, Calderwood SB, Steinhaus DM, Karchmer AW. Cardiac conduction abnormalities complicating native valve active infective endocarditis. Am J Cardiol. 1986;58:1213–7.
Habib G, Badano L, Tribouilloy C, Vilacosta I, Zamorano JL, Galderisi M. Recommendations for the practice of echocardiography in infective endocarditis. Eur J Echocardiogr. 2010;11:202–19.
Feuchtner GM, Stolzmann P, Dichtl W, Schertler T, Bonatti J, Scheffel H, et al. Multislice computed tomography in infective endocarditis: comparison with transesophageal echocardiography and intraoperative findings. J Am Coll Cardiol. 2009;53:436–44.
Gahide G, Bommart S, Demaria R, Sportouch C, Dambia H, Albat B, et al. Preoperative evaluation in aortic endocarditis: findings on cardiac CT. Am J Roentgenol. 2010;194:574–8.
Mahmood M, Kendi AT, Ajmal S, Farid S, O’Horo JC, Chareonthaitawee P, et al. Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis. J Nucl Cardiol. 2019;26:922–35.
Brancheau D, Degheim G, Machado C. Timing for pacing after acquired conduction disease in the setting of endocarditis. Case Reports in Cardiology. 2015;2015.
Bonaros N, Czerny M, Pfausler B, Müller S, Bartel T, Thielmann M, et al. Infective endocarditis and neurologic events: indications and timing for surgical interventions. Eur Heart J Suppl. 2020;22:M19–25.
O’Connor S, Andrew P, Batt M, Becquemin JP. A systematic review and meta-analysis of treatments for aortic graft infection. J Vasc Surg. 2006;44:38–45.
Shimamura J, Montanhesi P, Fuji S, Linrui G, Chu MWA. Ross procedure for acute infective endocarditis. J Card Surg. 2022;37:3964–6. https://doi.org/10.1111/jocs.16951. Epub 2022 Sep 18.
Nagpal A, Sohail M, Steckelberg J. Prosthetic valve endocarditis: state of the heart. Clin Invest. 2012;2:803–17.
Lalani T, Chu V, Park L. In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. AMA Intern Med. 2013;173:1495–504.
Kang D, Yong-Jin K, Sung-Han K. Early Surgery versus Conventional Treatment for Infective Endocarditis. N Engl J Med. 2012;366:2466–73.
Pettersson GB, Hussain ST. Current AATS guidelines on surgical treatment of infective endocarditis. Ann Cardiothorac Surg. 2019;8:630–44. https://doi.org/10.21037/acs.2019.10.05.
Szczechowicz, M, Weymann A, Mkalaluh S, Mashhour A , Zhigalov K , Easo J. Surgical options for aortic root replacement in destructive endocarditis. Braz J Cardiovasc Surg. 2020;35:265–273.
Wojnarski CM, Chodavadia PA, Barac YD, Armstrong JL, Vekstein AM, Haney JC, et al. Long-term outcomes of aortic root replacement for endocarditis. J Card Surg. 2021;36:1969–78. https://doi.org/10.1111/jocs.15472. Epub 2021 Mar 2.
Musci M, Weng Y, Hübler M, Amiri A, Pasic M, Kosky S, et al. Homograft aortic root replacement in native or prosthetic active infective endocarditis: twenty-year single-center experience. J Thorac Cardiovasc Surg. 2010;139:665–73.
Sabik JF, Lytle BW, Blackstone EH, Marullo AG, Pettersson GB, Cosgrove DM. Aortic root replacement with cryopreserved allograft for prosthetic valve endocarditis. Ann Thorac Surg. 2002;74:650–9; discussion 659. https://doi.org/10.1016/s0003-4975(02)03779-7.
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MWC has received Speakers’ honoraria from Medtronic, Edwards Lifesciences, Terumo Aortic and Artivion. The other authors have no relevant financial or non-financial interests to disclose.
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Muhanad Algadheeb, MBBS and Mohsyn Malik, MD are co-first authors.
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Algadheeb, M.S., Malik, M.I., Besa-Bandeira, S. et al. Contemporary surgical management of infective endocarditis of the aortic root. Indian J Thorac Cardiovasc Surg 40 (Suppl 1), 83–92 (2024). https://doi.org/10.1007/s12055-023-01604-6
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DOI: https://doi.org/10.1007/s12055-023-01604-6