Skip to main content
Log in

Nobel Prize in Physiology or Medicine 2019

  • General Article
  • Published:
Resonance Aims and scope Submit manuscript

Abstract

The Nobel Prize in Physiology or Medicine, 2019 was awarded jointly to William G. Kaelin Jr. of Dana-Farber Cancer Institute, Sir Peter J. Ratcliffe of Francis Crick Institute and University of Oxford and Gregg L. Semenza of Johns Hopkins University for their discovery of how cells sense and respond to varying oxygen levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Suggested Reading

  1. https://www.nobelprize.org/prizes/medicine/1938/summary/

  2. https://www.nobelprize.org/prizes/medicine/2019/summary/

  3. G L Semenza, M K Nejfelt, S M Chi, and S E Antonarakis, Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene, Proc Natl Acad Sci U S A., Vol.88, pp.5680–5684, 1991b.

    Article  Google Scholar 

  4. G L Semenza and G L Wang, A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation, Mol. Cell Biol., Vol.12, pp.5447–5454, 1992.

    Article  Google Scholar 

  5. G L Wang and G L Semenza, General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia, Proc Natl Acad Sci USA., Vol.90, pp.4304–4308, 1993.

    Article  Google Scholar 

  6. G L Wang and G L Semenza, Purification and characterization of hypoxia-inducible factor 1, J Biol Chem., Vol.270, pp.1230–1237, 1995.

    Article  Google Scholar 

  7. J C Chappell, L B Payne and W K Rathmell, Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers, J Clin Invest, Vol.129 pp.442–451, 2019.

    Article  Google Scholar 

  8. S Salceda and J Caro, Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes, J Biol Chem., Vol.272, pp.22642–22647, 1997.

    Article  Google Scholar 

  9. https://www.nobelprize.org/prizes/chemistry/2004/summary/

  10. P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher and P J Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, Vol.399, pp.271–275, 1999.

    Article  Google Scholar 

  11. P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield, P H Maxwell, C W Pugh and P J Ratcliffe, Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, Vol.292, pp.468–472, 2001.

    Article  Google Scholar 

  12. M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane and W G Kaelin Jr, HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, Vol.292 pp.464–468, 2001.

    Article  Google Scholar 

  13. G L Semenza, Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology, Annu Rev Pathol., Vol.9, pp.47–71, 2014.

    Article  Google Scholar 

  14. N Chen, C Hao, B C Liu BC, H Lin, C Wang, C Xing, X Liang, G Jiang, Z Liu, X Li, L Zuo, L Luo, J Wang, M H Zhao, Z Liu, G Y Cai, L Hao, R Leong, C Wang, C Liu, T Neff, L Szczech and K P Yu, Roxadustat treatment for anemia in patients undergoing long-term dialysis, N Engl J Med, Vol.381, pp.1011–1022, 2019.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mamatha M. Reddy.

Additional information

Mamatha M. Reddy is a scientist at LV Prasad Eye Institute, Bhubaneswar. She received her PhD in Biochemistry from the Indian Institute of Science, Bengaluru and did a postdoctoral fellowship at Dana-Farber Cancer Institute, Boston. Mamatha Reddy is a cancer biologist with interest in understanding molecular mechanisms of retinoblastoma tumor progression.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reddy, M.M. Nobel Prize in Physiology or Medicine 2019. Reson 24, 1375–1380 (2019). https://doi.org/10.1007/s12045-019-0904-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12045-019-0904-3

Keywords

Navigation