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One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition

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Abstract

An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO3H)3/SiO2(SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. Both aromatic and aliphatic aldehyde reacted well to give the corresponding amines in excellent yields. All the products are known and well-characterized. The catalyst is recoverable and could be easily recycled by filtration and reused several times without any significant loss of its activity. SBSA acts as a dual Brønsted/Lewis acid that is an air-stable and cost-effective solid acid.

An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones in the presence of sodium borohydride by using B(OSO3H)3/SiO2(SBSA) as the reusable solid catalyst in acetonitrile and under solvent-free conditions is described.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    HOSEIN HAMADI & SAMIRA JAVADI

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  1. HOSEIN HAMADI
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  2. SAMIRA JAVADI
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Correspondence to HOSEIN HAMADI.

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Supplementary Information (SI)

All additional information pertaining to characterization of the products and catalyst using NMR technique (Figures S3–S5) and IR spectra (Figures S1, S6–S23) are given in the supporting information. Supplementary Information is available at http://www.ias.ac.in/chemsci.

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HAMADI, H., JAVADI, S. One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition. J Chem Sci 129, 75–80 (2017). https://doi.org/10.1007/s12039-016-1208-8

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  • DOI: https://doi.org/10.1007/s12039-016-1208-8

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