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Synthesis of New dihydropyrimidinones catalysed by dicationic ionic liquid

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Abstract

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]-1H-imidazolium dibromide (C3 [min]2 2 [Br − ] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route.

A convenient multistep synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines.

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Authors and Affiliations

  1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431 004, India

    DHANAJI V JAWALE, UMESH R PRATAP, APARNA A MULAY, JYOTIRLING R MALI & RAMRAO A MANE

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  1. DHANAJI V JAWALE
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  2. UMESH R PRATAP
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JAWALE, D.V., PRATAP, U.R., MULAY, A.A. et al. Synthesis of New dihydropyrimidinones catalysed by dicationic ionic liquid. J Chem Sci 123, 645–655 (2011). https://doi.org/10.1007/s12039-011-0127-y

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