Skip to main content
SpringerLink
Log in

Keratins: Markers of cell differentiation or regulators of cell differentiation?

  • Commentary
  • Published:
Journal of Biosciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Buhler H and Schaller G 2005 Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo; Mol. Cancer Res. 3 365–371

    Article  PubMed  Google Scholar 

  • Casanova M L, Bravo A, Martinez-Palacio J, Fernandez-Acenero M J, Villanueva C, Larcher F, Conti C J and Jorcano J L 2004 Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice; FASEB J. 18 1556–1568

    PubMed  CAS  Google Scholar 

  • Caulin C, Ware C F, Magin T M and Oshima R G 2000 Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis; J. Cell Biol. 149 17–22

    Article  PubMed  CAS  Google Scholar 

  • Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop D R and Koch P J 2006 An unexpected role for keratin 10 end domains in susceptibility to skin cancer; J. Cell Sci. 119 5067–5076

    Article  PubMed  CAS  Google Scholar 

  • Clausen G, Moc D, Buschard K and Dabelstein E 1986 Keratin proteins in human oral mucosa; J. Oral Pathol. 15 36–42

    Article  PubMed  CAS  Google Scholar 

  • Coulombe P A and Omary M B 2002 “Hard” and “soft” principles defining the structure, function and regulation of keratin intermediate filaments; Curr. Opin. Cell Biol. 14 110–122

    Article  PubMed  CAS  Google Scholar 

  • Franke W W, Schmid E and Schiller D L 1982 Differentiation related patterns of expression of proteins of intermediate filaments in tissues and cultured cells; Cold Spring Harbor Symp. Quant. Biol. 46 431–531

    PubMed  Google Scholar 

  • Gijbels M J, van der Ham F, van Bennekum A M, Hendriks H F and Roholl P J 1992 Alterations in cytokeratin expression precede histological changes in epithelia of vitamin A-deficient rats; Cell Tissue Res. 268 197–203

    Article  PubMed  CAS  Google Scholar 

  • Gilbert S, Loranger A, Daigle N, Marceau N 2001 Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation; J. Cell Biol. 154 763–773

    Article  PubMed  CAS  Google Scholar 

  • Gilbert S, Loranger A and Marceau N 2004 Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells; Mol. Cell Biol. 24 7072–7081

    Article  PubMed  CAS  Google Scholar 

  • Hendrix M J C, Seftor E A, Chu Y W, Trevor K T and Seftor R E B 1996 Role of intermediate filaments in migration, invasion and metastasis; Cancer Metastasis Rev. 15 507–525

    Article  PubMed  CAS  Google Scholar 

  • Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T and Inagaki M 2001 Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD; J. Cell Biol. 155 415–426

    Article  PubMed  CAS  Google Scholar 

  • Kim S, Wong P and Coulombe P A 2006 A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth; Nature (London) 441 362–365

    Article  CAS  Google Scholar 

  • Ku N O, Liao J, Chou C F and Omary M.B 1996 Implications of intermediate filament protein phosphorylation; Cancer Metastasis Rev. 15 429–444

    Article  PubMed  CAS  Google Scholar 

  • Ku N O, Michie S, Resurreccion E Z, Broome R L and Omary M B 2002 Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression; Proc. Natl. Acad. Sci. USA 99 4373–4378

    Article  PubMed  CAS  Google Scholar 

  • Magin T M, Hesse M and Schröder R 2000 Novel insights into intermediate-filament function from studies of transgenic and knockout mice; Protoplasma 211 140–150

    Article  CAS  Google Scholar 

  • Magin T M, Reichelt J and Chen J 2005 The role of keratins in epithelial homeostasis; in Skin barrier (eds) P M Elias and K R Feingold (New york: Taylor and Francis) pp 141–170

    Google Scholar 

  • Maytin E V, Lin J C, Krishnamurthy R, Batchvarova N, Ron D, Mitchell P J and Habener J F 1999 Keratin 10 expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2; Dev. Biol. 216 164–181

    Article  PubMed  CAS  Google Scholar 

  • McGowan K and Coulombe P A 1998 The wound repair-associated keratins K6, K16 and K17: insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture; Subcell. Biochem. 31 173–204

    PubMed  CAS  Google Scholar 

  • Moll R, Franke W W, Schiller D L, Geiger B and Krepler R 1982 The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells; Cell 31 11–24

    Article  PubMed  CAS  Google Scholar 

  • Omary M B, Coulombe P A and McLean W H 2004 Intermediate filament proteins and their associated diseases; N. Engl. J. Med. 351 2087–2100

    Article  PubMed  CAS  Google Scholar 

  • Omary M B, Ku N O, Tao G Z, Toivola D M and Liao J 2006 “Heads and tails” of intermediate filament phosphorylation: multiple sites and functional insights; Trends Biochem. Sci. 31 383–394

    Article  PubMed  CAS  Google Scholar 

  • Paladini R D and Coulombe P A 1998 Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation; J. Cell Biol. 142 1035–1051

    Article  PubMed  CAS  Google Scholar 

  • Paramio J M, Segrelles C, Ruiz S and Jorcano J L 2001 Inhibition of protein kinase B (PKB) and PKC zeta mediates keratin K10-induced cell cycle arrest; Mol. Cell Biol. 21 7449–7459

    Article  PubMed  CAS  Google Scholar 

  • Ranganathan K, Kavitha R, Sawant S S and Vaidya M M 2006 Cytokeratin expression in oral submucous fibrosis — an immunohistochemical study; J. Oral Pathol. Med. 35 25–32

    Article  PubMed  CAS  Google Scholar 

  • Raul U B, Sawant S S, Dange P P, Kalraiya R D and Vaidya M M 2004 Implications of CK 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype; Int. J. Cancer 111 662–668

    Article  PubMed  CAS  Google Scholar 

  • Reichelt J and Magin T M 2002 Hyperproliferation, induction of c-Myc and 14-3-3σ, but no cell fragility in keratin-10-null mice; J. Cell Sci. 115 2639–2650

    PubMed  CAS  Google Scholar 

  • Roop D R, Krieg T M, Mehrel T, Cheng C K and Yuspa S H 1988 Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis; Cancer Res. 48 3245–3252

    PubMed  CAS  Google Scholar 

  • Santos M, Paramio J M, Bravo A, Ramirez A and Jorcano J L 2002 The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis; J. Biol. Chem. 277 19122–19130

    Article  PubMed  CAS  Google Scholar 

  • Santos M, Río P, Ruiz S, Martínez-Palacio J, Segrelles C, Lara M F, Segovia J C and Paramio J M 2005 Altered T cell differentiation and notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus; J. Cell Biochem. 95 543–558

    Article  PubMed  CAS  Google Scholar 

  • Swaf M H, Ouhayoum J P, Shabana A H M and Forest N 1990 Cytokeratin expression in human tongue epithelium; Am. J. Anat. 189 155–166

    Article  Google Scholar 

  • Toivola D M, Krishnan S, Binder H J, Singh S K and Omary M B 2004 Keratins modulate colonocyte electrolyte transport via protein mistargeting; J. Cell Biol. 164 911–921

    Article  PubMed  CAS  Google Scholar 

  • Tong X and Coulombe P A 2006 Keratin 17 modulates hair follicle cycling in a TNFα dependent fashion; Genes Dev. 20 1353–1364

    Article  PubMed  CAS  Google Scholar 

  • Vaidya M M, Borges A M, Pradhan S A and Bhisey A N 1996 Cytokeratin expression in squamous cell carcinomas of the tongue and alveolar mucosa; Eur. J. Cancer B. Oral Oncol. 32B 333–336

    Article  PubMed  CAS  Google Scholar 

  • Vaidya M M, Borges A M, Pradhan S A, Rajpal R M and Bhisey A N 1989 Altered keratin expression in buccal mucosal squamous cell carcinoma; J. Oral Pathol. Med. 18 282–286

    Article  PubMed  CAS  Google Scholar 

  • Vaidya M M, Sawant S S, Borges A M, Ogale S B and Bhisey A N 1998 Cytokeratin expression in precancerous lesions of the human oral cavity; Oral Oncol. 34 261–264

    PubMed  CAS  Google Scholar 

  • Vigneshwaran N, Peters K P, Hornstein O P and Haneke E 1989 Comparison of cytokeratin, filaggrin and involucrin profiles in oral leukoplakias and squamous carcinomas; J. Oral Pathol. Med. 18 377–390

    Article  Google Scholar 

  • Wang Y N and Chang W C 2003 Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun; J. Biol. Chem. 278 45848–45857

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, KS 110-111, Vaidya Lab, Cancer Research Institute, Kharghar, Navi Mumbai, Maharashtra, 410 210, India

    Milind M. Vaidya & Deepak Kanojia

Authors
  1. Milind M. Vaidya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Deepak Kanojia
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vaidya, M.M., Kanojia, D. Keratins: Markers of cell differentiation or regulators of cell differentiation?. J Biosci 32, 629–634 (2007). https://doi.org/10.1007/s12038-007-0062-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12038-007-0062-8

Keywords

Search

Navigation