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Role of Peptidylarginine Deiminase 4 in Central Nervous System Diseases

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Abstract

The deimination or citrullination of arginine residues in the polypeptide chain by peptidylarginine deiminase 4 alters the charge state of the polypeptide chain and affects the function of proteins. It is one of the main ways of protein post-translational modifications to regulate its function. Peptidylarginine deiminase 4 is widely expressed in multiple tissues and organs of the body, especially the central nervous system, and regulates the normal development of organisms. The abnormal expression and activation of peptidylarginine deiminase 4 is an important pathological mechanism for the occurrence and development of central nervous system diseases such as multiple sclerosis, Alzheimer’s disease, cerebral ischemia reperfusion injury, and glioblastoma.

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Funding

This work was supported by Henan Province science and technology research and development (232102310495,222102310434), and Innovation and entrepreneurship training program for college students of Henan University (20221014003,20221014008).

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Authors and Affiliations

  1. Institute of Chronic Disease Risks Assessment, School of Nursing and Health Sciences, Henan University, Henan Province, Kaifeng, 475004, People’s Republic of China

    Huixia Geng, Qihang An & Lai Wang

  2. School of Life Science, Henan University, Henan Province, Kaifeng, 475004, People’s Republic of China

    Yanshuo Zhang, Yunhang Huang, Lai Wang & Yanming Wang

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  1. Huixia Geng
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All authors read and approved the final version of the manuscript. HXG and QHA contributed to writing the manuscript. YHH, YSZ, and LW. made the visualization. LW and YW designed and wrote this research.

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Correspondence to Lai Wang or Yanming Wang.

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Geng, H., An, Q., Zhang, Y. et al. Role of Peptidylarginine Deiminase 4 in Central Nervous System Diseases. Mol Neurobiol 60, 6748–6756 (2023). https://doi.org/10.1007/s12035-023-03489-3

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