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Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124

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Abstract

miR-124 is a miRNA predominantly expressed in the nervous system and accounts for more than a quarter of the total miRNAs in the brain. It regulates neurogenesis, neuronal differentiation, neuronal maturation, and synapse formation and is the most important miRNA in the brain. Furthermore, emerging evidence has suggested miR-124 may be associated with the pathogenesis of various neurodevelopmental and neuropsychiatric disorders. Here, we provide an overview of the role of miR-124 in neurodevelopment and the underling mechanisms, and finally, we prospect the significance of miR-124 research to the field of neuroscience.

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Funding

This work was supported by the National Natural Science Foundation of China (82271198), the Joint Funds for the Innovation of Science and Technology of Fujian province (No.2018Y9068), the Natural Science Foundation of Guangdong province (2018A030313008), the Natural Science Foundation of Fujian Province (No. 2020J01598), and the funds of Fujian Medical University (XRCZX2019009).

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  1. Xi Gu and Xiaona Xu contributed equally to the writing of the article.

Authors and Affiliations

  1. Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

    Xi Gu, Junhao Wang, Jiwen Zhang, Qiong Gao & Jiawei Chen

  2. Department of Obstetrics and Gynecology, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Xiaona Xu

  3. Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

    Chunhong Jia

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XG and XNX designed and wrote the manuscript. CHJ contributed to manuscript preparation and reviewing. JHW, JWZ, QG, and JWC help to check for language errors.

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Gu, X., Xu, X., Jia, C. et al. Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124. Mol Neurobiol 60, 3569–3583 (2023). https://doi.org/10.1007/s12035-023-03271-5

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