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Therapeutic Effect of Transplanted Human Wharton’s Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis

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Abstract

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS is cell transplantation which may promote remyelination. We transplanted human Wharton’s jelly stem cell-derived oligodendrocyte progenitor cells (hWJ-MSC-derived OPCs) into the brain ventricles of mice induced with experimental autoimmune encephalomyelitis (EAE), the animal model of MS. We studied the effect of the transplanted OPCs on the functional and pathological manifestations of the disease. Transplanted hWJ-MSC-derived OPCs significantly reduced the clinical signs of EAE. Histological examinations showed that remyelination was significantly increased after transplantation. These results suggest that hWJ-MSC-derived OPCs promote the regeneration of myelin sheaths in the brain.

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Acknowledgments

We thank the Iran National Science Foundation for the financial supports (INSF) and the Cellular & Molecular Research Center of Iran University of Medical Sciences for providing us the facilities.

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Authors and Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Elmira Mikaeili Agah & Kazem Parivar

  2. Iran National Science Foundation (INSF), Tehran, Iran

    Kazem Parivar

  3. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    Mohammad Taghi Joghataei

Authors
  1. Elmira Mikaeili Agah
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  2. Kazem Parivar
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  3. Mohammad Taghi Joghataei
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Correspondence to Elmira Mikaeili Agah.

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Mikaeili Agah, E., Parivar, K. & Joghataei, M.T. Therapeutic Effect of Transplanted Human Wharton’s Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis. Mol Neurobiol 49, 625–632 (2014). https://doi.org/10.1007/s12035-013-8543-2

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  • DOI: https://doi.org/10.1007/s12035-013-8543-2

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