Skip to main content
SpringerLink
Log in

Nano-cubes over nano-spheres: shape dependent study of silver nanomaterial for biological applications

  • Published:
Bulletin of Materials Science Aims and scope Submit manuscript

Abstract

Silver nanomaterials (AgNMs) ubiquitously known for their biological applications are studied here in terms of their shape-dependent antibacterial and anti-biofilm effect. Chemically synthesized nano-cubes (AgNCs) with size range around 150–200 nm were compared for their biological activity with commercial nano-sphere (AgNS) of comparable size (~160 nm). The antibacterial activity against both Escherichia coli and Staphylococcus aureus showed higher activity for nano-cubes compared with nano-spheres.The synergistic role of AgNMs with antibiotic ampicillin was also found promising. A four times enhancement and an increase of nearly 25% of antibiotic activity at 0.0625 mg ml–1 concentration was found with 0.05 mg ml–1 of AgNCs in agar and broth media, respectively. Anti-biofilm effect towards E. coli and S. aureus was also evaluated. AgNCs showed equal importance in biofilm disruption with 20% inhibition activity, which was yet again found better in-comparison with AgNSs. The study shows that AgNCs with distinct faces and edges could show efficient anti-bacterial effect and so such intelligently designed material could pave path for imminent medical challenges.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6

Similar content being viewed by others

Reference

  1. Zeng J, Zhang Q, Chen J and Xia Y A 2010 Nano Lett. 10 30

    Article  CAS  Google Scholar 

  2. Khlebtsov B N, Zharov V P, Melnikov A G, Tuchin V V and Khlebtsov N G 2006 Nanotechnology 17 5167

    Article  CAS  Google Scholar 

  3. Kim M J, Cho Y S, Park Y S and Huh Y D 2012 Cryst. Growth Des. 12 4180

    Article  CAS  Google Scholar 

  4. Shenashen Mohamed A, El-Safty Sherif A and Elshehy Emad A 2014 Part. Part. Syst. Charact. 3 293

    Article  CAS  Google Scholar 

  5. Sun Y and Xia Y 2002 Science 298 2176

    Article  CAS  Google Scholar 

  6. Kim D, Jeong S and Moon J 2006 Nanotechnology 17 4019

    Article  CAS  Google Scholar 

  7. Chen M, Feng Y-G, Wang X, Li T-C, Zhang J-Y and Qian D-J 2007 Langmuir 23 5296

    Article  CAS  Google Scholar 

  8. Rivas L and Garcı J V 2001 Langmuir 17 574

    Article  CAS  Google Scholar 

  9. Lee K J, Jun B H, Kim T H and Joung J 2006 Nanotechnology 17 2424

    Article  CAS  Google Scholar 

  10. Mishra Y K, Mohapatra S and Kabiraj D 2007 Scri. Mater. 56 629

    Article  CAS  Google Scholar 

  11. Ashkarran A A 2010 Curr. Appl. Phys. 10 1442

    Article  Google Scholar 

  12. Zhang Q, Ge J, Pham T, Goebl J, Hu Y, Lu Z et al 2009 Angew. Chem. 19 3568

    Article  Google Scholar 

  13. Gliga Anda R, Sara Skoglund, Odnevall Wallinder Inger, Bengt Fadeel and Karlsson Hanna L 2014 Part. Fibre Toxicol. 11 11

    Article  CAS  Google Scholar 

  14. Wiley Benjamin, Sun Yugang and Xia Younan 2007 Acc. Chem. Res. 10 1067

    Article  CAS  Google Scholar 

  15. Pal S, Tak Y K and Song J M 2007 Appl. Env. Microbiol. 73 1712

    Article  CAS  Google Scholar 

  16. Lee C R, Cho I H, Jeong B C and Lee S H 2013 Int. J. Env. Res. Public Health 10 4274

    Article  CAS  Google Scholar 

  17. Wright G D 2010 BMC Biol. 1 123

    Article  Google Scholar 

  18. Nafeesa Khatoon, Hammad Alam, Afreen Khan, Khalid Raza and Meryam Sardar 2019 Sci. Rep. 9 6848

    Article  CAS  Google Scholar 

  19. Zou L, Wang J, Gao Y, Ren X, Rottenberg M E, Lu J et al 2018 Sci. Rep. 8 11131

    Article  CAS  Google Scholar 

  20. Hwang I S, Hwang J H, Choi H, Kim K J and Lee D G 2012 J. Med. Microbiol. 12 1719

    Article  CAS  Google Scholar 

  21. Costerton J W, Cheng K J, Geesey G G, Ladd I T, Nickel J C and Dasgupta M 1987 Ann. Rev. Microbiol. 1 435

    Article  Google Scholar 

  22. Gristina A G, Hobgood C D, Web L X and Myrvik Q N 1987 Biomaterial 8 423

    Article  CAS  Google Scholar 

  23. Gagner J E, Shrivastava S, Qian X, Dordick J S and Siegel R W 2012 J. Phys. Chem. Lett. 3 3149

    Article  CAS  Google Scholar 

  24. Ramasamy M, Lee J H and Lee J 2017 Colloids Surf. B 160 639

    Article  CAS  Google Scholar 

  25. Gurunathan S, Han J W, Kwon D N and Kim J H 2014 Nanoscale Res. Lett. 9 373

    Article  CAS  Google Scholar 

  26. Singh P, Pandit S, Beshay M, Mokkapati V R, Garnaes J, Olsson M E et al 2018 Biotechnol. S3 S886

    Google Scholar 

  27. Rajalakshmi Ramachandran and Sangeetha D 2017 J. Pharma Innov. 11 36

  28. Srivastava A K, Punam Awasthi, Sanjay Kanojia, Neeraj N S, Pankaj Sharma, Kingsuk Mukhopadhyay et al 2018 Defence Sci. J. 68 98

    Article  CAS  Google Scholar 

  29. Shrivastava S 2007 Nanotechnology 18 225103

    Article  CAS  Google Scholar 

  30. Ren J, Wang W Z, Sun S M, Zhang L, Wang L and Chang J 2011 Ind. Eng. Chem. Res. 50 10366

    Article  CAS  Google Scholar 

  31. Pal S, Tak Y K and Song J M 2007 Appl. Environ. Microbiol. 73 1712

    Article  CAS  Google Scholar 

  32. Hong Xuesen, Wen Junjie, Xiong Xuhua and Yongyou Hu 2016 Environ. Sci. Pollut. Res. 23 4489

    Article  CAS  Google Scholar 

  33. Stoehr Linda C, Edgar Gonzalez, Andreas Stampfl, Eudald Casals, Albert Dusch, Victor Puntes et al 2011 Part. Fibre Toxicol. 8 36

    Article  CAS  Google Scholar 

  34. Durán N, Silveira C P, Durán M and Martinez D S T 2015 J. Nanobiotechnol. 13 55

    Article  CAS  Google Scholar 

  35. Argentiere S, Cella C, Cesaria M, Milani P and Lenardi C 2016 J. Nanopart. Res. 18 253

    Article  CAS  Google Scholar 

  36. Akter M, Sikder M T, Rahman M M, Ullah A K M A, Hossain K F B, Banik S et al 2018 J. Adv. Res. 9 1

    Article  CAS  Google Scholar 

  37. Sadeghi B, Garmaroudi F S, Hashemi M, Nezhad H R, Nasrollahi A, Ardalan S et al 2012 Adv. Powder Technol. 23 22

    Article  CAS  Google Scholar 

  38. Wilson H L, Daveson K and Del Mar C B 2019 Aust. Prescr. 42 5

    Article  Google Scholar 

  39. Korani M, Ghazizadeh E, Korani S, Hami Z and Mohammadi-Bardbori A 2015 Eur. J. Nanomed. 7 51

    Article  CAS  Google Scholar 

  40. Zannatul Ferdous and Abderrahim Nemmar 2020 Int. J. Mol. Sci. 21 2375

    Article  CAS  Google Scholar 

  41. Schinwald A, Chernova T and Donaldson K 2012 Part. Fibre Toxicol. 9 47

    Article  CAS  Google Scholar 

  42. Schinwald A and Donaldson K 2012 Part. Fibre Toxicol. 9 34

    Article  CAS  Google Scholar 

  43. Schinwald A, Murphy F A, Prina-Mello A, Poland C A, Byrne F, Movia D et al 2012 Toxicol. Sci. 128 461

    Article  CAS  Google Scholar 

  44. George S, Lin S, Jo Z, Thomas C R, Li L, Mecklenburg M et al 2012 ACS Nano 6 3745

    Article  CAS  Google Scholar 

  45. Scanlan L D, Reed R B, Loguinov A V, Antczak P, Tagmount A, Aloni S et al 2013 ACS Nano 7 10681

    Article  CAS  Google Scholar 

  46. Singh A, Prasad D N, Singh S B and Kohli E 2017 J. Hazard. Mater. 327 180

    Article  CAS  Google Scholar 

  47. Singh A, Gahlot U, Prasad DN, A and Eta Kohli 2019 Nanotoxicology 13 7

Download references

Acknowledgements

This study was supported by the grants from DIPAS, DRDO, Government of India. Priyanka Mishra and Rahul Ranjan are thankful to DRDO fellowship. We are also thankful to Ms. Simran Mehta and Dimple Sharma, intern students from Maharishi Markandeshwar University, as a helping hand.

Author information

Authors and Affiliations

  1. Department of Neurobiology, DIPAS, DRDO, Delhi, 110054, India

    Neha Agrawal, Rahul Ranjan, Deepti Prasad & Ekta Kohli

  2. Department of Immunomodulation, DIPAS, DRDO, Delhi, 110054, India

    Priyanka Mishra

  3. Directorate of Nanotechnology, DMSRDE, DRDO, Kanpur, 208013, India

    Punam Awasthi & Alok Srivastava

Authors
  1. Neha Agrawal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Priyanka Mishra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rahul Ranjan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Punam Awasthi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alok Srivastava
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Deepti Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ekta Kohli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neha Agrawal.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 361 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Agrawal, N., Mishra, P., Ranjan, R. et al. Nano-cubes over nano-spheres: shape dependent study of silver nanomaterial for biological applications. Bull Mater Sci 44, 191 (2021). https://doi.org/10.1007/s12034-021-02487-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12034-021-02487-2

Keywords

Search

Navigation