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Bioinformatics Analysis of miR-181a and Its Role in Adipogenesis, Obesity, and Lipid Metabolism Through Review of Literature

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Abstract

The miRNAs regulate various biological processes in the mammalian body system. The role of miR-181a in the development, progression, and expansion of cancers is well-documented. However, the role of miR-181a in adipogenesis; lipid metabolism; obesity; and obesity-related issues such as diabetes mellitus needs to be explored. Therefore, in the present study, the literature was searched and bioinformatics tools were applied to explore the role of miR-181a in adipogenesis. The list of adipogenic and lipogenic target genes validated through different publications were extracted and compiled. The network and functional analysis of these target genes was performed through in-silico analysis. The mature sequence of miR-181a of different species were extracted from and were found highly conserved among the curated species. Additionally, we also used various bioinformatics tools such as target gene extraction from Targetscan, miRWalk, and miRDB, and the list of the target genes from these different databases was compared, and common target genes were predicted. These common target genes were further subjected to the enrichment score and KEGG pathways analysis. The enrichment score of the vital KEGG pathways of the target genes is the key regulator of adipogenesis, lipogenesis, obesity, and obesity-related syndromes in adipose tissues. Therefore, the information presented in the current review will explore the regulatory roles of miR-181a in fat tissues and its associated functions and manifestations.

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Funding

The study was supported by Key scientific research project of Henan University through project number 23B180007.

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  1. Medical College of Xuchang University, No.1389, Xufan Road, Xuchang City, 461000, Henan Province, People’s Republic of China

    Guo Hongfang

  2. Department of Livestock Management, Breeding and Genetics, The University of Agriculture, Peshawar, 25130, Pakistan

    Rajwali Khan

  3. Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia

    Ahmed A. El-Mansi

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GHF and RWK: Conceptualization. GHF and RWK: methodology. GHF and RWK: software. GHF and RWK: formal analysis. GHF and RWK: writing—original draft preparation. GHF, RWK and AAE: writing—review and editing. All authors have read and agreed to the published version of the manuscript.

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Hongfang, G., Khan, R. & El-Mansi, A.A. Bioinformatics Analysis of miR-181a and Its Role in Adipogenesis, Obesity, and Lipid Metabolism Through Review of Literature. Mol Biotechnol (2023). https://doi.org/10.1007/s12033-023-00894-w

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