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PinX1 inhibits cell proliferation, migration and invasion in glioma cells

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Abstract

PinX1 induces apoptosis and suppresses cell proliferation in some cancer cells, and the expression of PinX1 is frequently decreased in some cancer and negatively associated with metastasis and prognosis. However, the precise roles of PinX1 in gliomas have not been studied. In this study, we found that PinX1 obviously reduced the gliomas cell proliferation through regulating the expressions of cell cycle-relative molecules to arrest cell at G1 phase and down-regulating the expression of component telomerase reverse transcriptase (hTERT in human), which is the hardcore of telomerase. Moreover, PinX1 could suppress the abilities of gliomas cell wound healing, migration and invasion via suppressing MMP-2 expression and increasing TIMP-2 expression. In conclusion, our results suggested that PinX1 may be a potential suppressive gene in the progression of gliomas.

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Acknowledgments

This project is supported by grants from the National Natural Science Foundation of China (Nos. 81472663, 81201636), the Science and Technology Department of Jiangsu Province (No. BK2012139) and China Postdoctoral Science Foundation (No. 2014T70549, 2012M511323).

Conflict of interest

The authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, 221002, Jiangsu Province, China

      Peng-Jin Mei, Yan-Su Chen, Ying Du, Jin Bai & Jun-Nian Zheng

    2. Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou, 221002, Jiangsu Province, China

      Peng-Jin Mei

    3. School of Public Health, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, 221002, Jiangsu Province, China

      Yan-Su Chen

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    1. Peng-Jin Mei
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    2. Yan-Su Chen
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    3. Ying Du
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    4. Jin Bai
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    5. Jun-Nian Zheng
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    Corresponding authors

    Correspondence to Jin Bai or Jun-Nian Zheng.

    Additional information

    Peng-Jin Mei and Yan-Su Chen contributed equally to this paper.

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    Mei, PJ., Chen, YS., Du, Y. et al. PinX1 inhibits cell proliferation, migration and invasion in glioma cells. Med Oncol 32, 73 (2015). https://doi.org/10.1007/s12032-015-0545-7

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