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Protective Effects of Zinc on Spinal Cord Injury

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Abstract

Spinal cord injury is a serious disease of the central nervous system, but there is no effective treatment. And zinc is an essential nutrient for human body and participates in many physiological processes, such as immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging. This article mainly summarizes that zinc could predict the prognosis and treat the spinal cord injury. Especially, zinc could help to inhibit inflammation, regulate autophagy, and reduce oxidative stress. However, excessive zinc will damage neurons.

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Funding

This work was supported by the National Natural Science Foundation of China (NSFC) (Nos. 81871556 and 82072165) and Liaoning Revitalization Talents Program (No. XLYC1902108).

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Authors and Affiliations

  1. Department of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, 121001, People’s Republic of China

    Shan Wen, Yuanlong Li, Xiaolei Shen, Zhe Wang, Kaihua Zhang, Jiawei Zhang & Xifan Mei

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  1. Shan Wen
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  2. Yuanlong Li
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Correspondence to Xifan Mei.

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Wen, S., Li, Y., Shen, X. et al. Protective Effects of Zinc on Spinal Cord Injury. J Mol Neurosci 71, 2433–2440 (2021). https://doi.org/10.1007/s12031-021-01859-x

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