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γ-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors

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Abstract

γ-Synuclein, also referred to as breast-cancer-specific gene 1, is the third member of the neuronal protein family synuclein. Synucleins attracted the attention of many investigators because of their role in human diseases. γ-Synuclein participates in the pathogenesis of several types of cancer and some neurodegenerative diseases. Its role in tumorigenesis is due to the upregulation of transcription and the effect on downstream targets, including signaling pathways and transcription factors. γ-Synuclein is also expressed in neurons and glial cells, but the regulation of its expression, as well as the mechanism of transition from normal functions to pathology in these cell types, is not studied. Here, we examined how γ-synuclein promoter is regulated in neuronal and glial cells. We also show that γ-synuclein is able to bind directly to several transcription factors. These results are discussed in connection with the implication of γ-synuclein in diseases.

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Acknowledgments

The authors would like to thank Neeraj Agarwal (University of North Texas Health Science Center, Fort Worth, TX, USA) for RGC-5 cells and Dr. H. Geller (Department of Pharmacology Robert Wood Johnson Medical School) for the culture of A7 astrocytes. This work is supported by NIH grant EY 02687, VA Merit Review grant, and The Glaucoma Foundation grant QB42308. The technical help of Ms. Kristin Cain is acknowledged.

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Authors and Affiliations

  1. Retinal Biology Research Laboratory, Veterans Administration Medical Center, 4801 East Linwood Boulevard, Kansas City, MO, 64128, USA

    Irina Surgucheva & Andrei Surguchov

  2. Department of Neurology, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas, KS, 66160, USA

    Irina Surgucheva & Andrei Surguchov

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  1. Irina Surgucheva
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  2. Andrei Surguchov
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Correspondence to Andrei Surguchov.

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Surgucheva, I., Surguchov, A. γ-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors. J Mol Neurosci 35, 267–271 (2008). https://doi.org/10.1007/s12031-008-9074-6

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  • DOI: https://doi.org/10.1007/s12031-008-9074-6

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