Skip to main content

Advertisement

SpringerLink
Log in

Endoscopic Chemotherapy with 5-Fluorouracil in Advanced Gastric Cancer

  • Brief Communication
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Introduction

It has been reported that a local injection of 5-fluorouracil (5-FU) administered endoscopically can have a favorable result in patients with early gastric cancer.

Methods

We report the application of a local injection of 5-FU administered endoscopically in three patients with advanced gastric cancer (AGC) who refused or were not suitable for surgery or systemic chemotherapy. The benefits of locally applied endoscopic chemotherapy (EC) with 5-FU as an alternative therapy were evaluated.

Results

Good tolerance with an important reduction of the tumor size and no adverse reactions was observed in all three patients.

Conclusion

EC with 5-FU is a feasible technique that can be applied in a certain group of patients with AGC. Further studies will be required to corroborate these results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.

    Article  PubMed  Google Scholar 

  2. NA. Anuario de estructuras vitales, nacimientos y defunciones. INEC, 2003.

  3. Marujama K, Okabayashi K, Kinoshita T. Progress in gastric cancer surgery in Japan and its limits of radicality. World J Surg. 1987;11:418–25.

    Article  Google Scholar 

  4. Roukos DH, Lorenz M, Encke A. Evidence of survival benefit of extended (D2) lymphadenectomy in western patients with gastric cancer based on a new concept: a prospective long-term follow-up study. Surgery. 1998;123:573–8.

    Article  CAS  PubMed  Google Scholar 

  5. Makuuchi H, Kise Y, Shimada H, Chino O, Tanaka H. Endoscopic mucosal resection for early gastric cancer. Seming Surg Oncol. 1997;17:108–16.

    Article  Google Scholar 

  6. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–30.

    Article  CAS  PubMed  Google Scholar 

  7. Al-Batran SE, Atmaca A, Hegewisch-Becker S, Jaeger D, Hahnfeld S, Rummel MJ, et al. Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer. J Clin Oncol. 2004;22:658–63.

    Article  CAS  PubMed  Google Scholar 

  8. Yamada K, Murphy GP, Douglass HO Jr. Comparison of intramural 5-fluorouracil and more conventional routes of drug administration on concentrations in gastric regional lymph nodes: a potential for trans-endoscopic adjuvant chemotherapy. J Surg Oncol. 1979;11:341–9.

    Article  CAS  PubMed  Google Scholar 

  9. Ohta H, Takagi K, Noguchi Y, Ohashi I, Takahashi T, Watanabe S, et al. Endoscopic intramural injection of anti-neoplastic emulsion. Gann. 1984;75:641–9.

    CAS  PubMed  Google Scholar 

  10. Ohtaki S, Kaneko H, Fukuma E, et al. Local injection of anti-cancer drug-oil suspension under endoscopic guidance for gastric carcinoma. J Jap Soc Cancer Ther. 1990;25:396.

    Google Scholar 

  11. Kuwayama H, Eastwood GL, Kohashi E, Honda T. Endoscopic local injection of early gastric carcinoma with 5-fluorouracil. Dig Dis Sci. 1984;29:498–501.

    Article  CAS  PubMed  Google Scholar 

  12. Ohyama T, Yamasaki J, Imanishi T, Ohgaki M, Tsujimoto H, Shirasu M, et al. Endoscopic injection of methotrexate bound to activated carbon particles in the treatment of gastric cancer. Gan To Kagaku Ryoho. 1995;22:1632–4.

    CAS  PubMed  Google Scholar 

  13. Monga SP, Wadleigh R, Adib H, Harmon JW, Berlin M, Mishra L. Endoscopic treatment of gastric cancer with intratumoral cisplatin/epinephrine injectable gel: a case report. Gastrointest Endosc. 1998;48:415–7.

    Article  CAS  PubMed  Google Scholar 

  14. NA. Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3.0, DCTD, NCI, NIH, DHHS, March 31, 2003 (http://ctep.cancer.gov), Publish Date: August 9, 2006. Available at URL address: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm.

Download references

Author information

Authors and Affiliations

  1. Gastroenterology Division, Instituto Ecuatoriano de Enfermedades Digestivas y Pelvicas (IECED), Portoviejo, Manabi, Ecuador

    Carlos Robles-Jara & Carlos Robles-Medranda

  2. Gastroenterology Division, Hôpital Edouard Herriot, Lyon, France

    Carlos Robles-Medranda

  3. Instituto Ecuatoriano de Enfermedades Digestivas y Pélvicas (IECED), Hospital Clinica San Antonio, Av. Paulo Emilio Macias y Tennis club, P.O. Box 13-01-266, Portoviejo, Manabi, Ecuador

    Carlos Robles-Jara

Authors
  1. Carlos Robles-Jara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carlos Robles-Medranda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carlos Robles-Jara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robles-Jara, C., Robles-Medranda, C. Endoscopic Chemotherapy with 5-Fluorouracil in Advanced Gastric Cancer. J Gastrointest Canc 41, 75–78 (2010). https://doi.org/10.1007/s12029-009-9112-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-009-9112-9

Keywords

Search

Navigation