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Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury

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A Correction to this article was published on 26 May 2023

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Abstract

Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a two-way pathway. The communication between the central nervous system and peripheral organs involves nerves, endocrine, and immunity systems as well as the emotional and cognitive centers of the brain. Particularly, acute brain injury is complicated by neuroinflammation and neurodegeneration causing multiorgan inflammation, microbial dysbiosis, gastrointestinal dysfunction and dysmotility, liver dysfunction, acute kidney injury, and cardiac dysfunction. Organ crosstalk has become increasingly popular, although the information is still limited. The present narrative review provides an update on the crosstalk between the nervous system and systemic organs after acute brain injury. Future research might help to target this pathophysiological process, preventing the progression toward multiorgan dysfunction in critically ill patients with brain injury.

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  1. Denise Battaglin, Silvia De Rosa, and Daniel Agustin Godoy all authors equally contributed.

Authors and Affiliations

  1. Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genoa, Italy

    Denise Battaglini

  2. Centre for Medical Sciences, University of Trento, Via S. Maria Maddalena 1, 38122, Trento, Italy

    Silvia De Rosa

  3. Anesthesia and Intensive Care, Santa Chiara Regional Hospital, APSS Trento, Trento, Italy

    Silvia De Rosa

  4. Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina

    Daniel Agustin Godoy

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DAG, DB, and SDR contributed to the article conception and design; analysis and interpretation of literature; drafting the article and revising it critically for important intellectual content; final approval of the version to be published; agreement on accuracy and integrity of any part of the work. All authors read and approved the final manuscript.

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Battaglini, D., De Rosa, S. & Godoy, D.A. Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury. Neurocrit Care 40, 337–348 (2024). https://doi.org/10.1007/s12028-023-01725-1

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