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Three-Dimensional Interactive and Stereotactic Human Brain Atlas of White Matter Tracts

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Abstract

We present a human brain atlas of white matter (WM) tracts containing 40 major tracts, which is three-dimensional (3D), segmented, labeled, interactive, stereotactic and correlated to structure and vasculature. We consider: 1) WM accuracy by correlating WM tracts to underlying neuroanatomy and quantifying them; 2) balance between realism and completeness by processing a sequence of track volumes generated for various parameters with the increasing track number to enable a tract “shape convergence”. MPRAGE and DTI in 64 directions of the same subject were acquired on 3 Tesla. The method has three steps: DTI-MPRAGE registration, 3D tract generation from DTI, to WM reconstruction from MPRAGE to parcellation into 17 components. 82 track volumes were generated for a wide spectrum of parameter values: Fractional Anisotropy threshold in [0.0125, 0.55] and trajectory angle lower than 45°,60°,65°,70°,75°,80°,85°,90°. For each tract, a sequence of track volumes was processed to create/edit contours delineating this tract to achieve its shape convergence. The parcellated tracts were grouped into commissures, associations, projections and posterior fossa tracts, and labeled following Terminologia Anatomica. To facilitate that, a dedicated tract editor is developed which processes multiple track volumes, handles tracts in three representations (tracks, contours, envelopes); provides editing/visualization simultaneously on axial, coronal, sagittal planes; enables tract labeling and coloring; and provides numerous tools (track counting, smoothing and length thresholding; representation conversion and saving; structural atlas support). A stereotactic tract atlas along with parcellated WM was developed to explore in real-time any individual tract or their groups along with surrounding neuroanatomy.

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Acknowledgements

This work was founded by Biomedical Research Council, Agency for Science, Technology and Research (A*STAR), Singapore. We are very grateful to Dr. Val M. Runge of Scott and White Clinic and Hospital, Temple, TX for acquiring the scans. The user interface (presented in Fig. 10) was esthetically designed by Natalia Nowinska.

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  1. Biomedical Imaging Lab, Agency for Science Technology and Research, 30 Biopolis Street, #07-01 Matrix, Singapore, 138671, Singapore

    Wieslaw L. Nowinski, Beng Choon Chua, Guo Liang Yang & Guo Yu Qian

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  1. Wieslaw L. Nowinski
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  2. Beng Choon Chua
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Correspondence to Wieslaw L. Nowinski.

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Nowinski, W.L., Chua, B.C., Yang, G.L. et al. Three-Dimensional Interactive and Stereotactic Human Brain Atlas of White Matter Tracts. Neuroinform 10, 33–55 (2012). https://doi.org/10.1007/s12021-011-9118-x

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