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A practical approach to normocalcemic primary hyperparathyroidism

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Abstract

Normocalcemic primary hyperparathyroidism is an entity on which several issues about its clinical management remains unclear. This is reflected in the main current guidelines, where there are no evidence-based specific recommendations. Through an exhaustive review of current literature, a clinical management algorithm for these patients is proposed. We consider the diagnosis criteria, the differential diagnosis, the clinical manifestations, and the treatment indications. When indicated, we also review the preoperative locations techniques and the surgical approach. Finally, when surgical treatment is not indicated, the patient is not a candidate to surgery or refuse surgical management, we review the medical treatment options and the follow-up schemes.

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Author contributions

Conceptualization, J.L.M.N. and M.M.A.; literature review and writing—original draft preparation, J.L.M.N., M.S.N. and I.H.M.; writing—review and editing, J.L.M.N., M.S.N., I.H.M. and M.M.A.; supervision, J.L.M.N. and M.M.A. All authors have read and agreed to the published version of the manuscript.

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Authors and Affiliations

  1. Department of General and Digestive Surgery, Hospital Universitario de la Princesa; Instituto de Investigación Sanitaria Princesa (ISS-IP); Universidad Autónoma de Madrid, Madrid, Spain

    José Luis Muñoz de Nova

  2. Department of Endocrinology and Nutrition, Hospital Universitario de la Princesa; Instituto de Investigación Sanitaria Princesa (ISS-IP); Universidad Autónoma de Madrid, Madrid, Spain

    Miguel Sampedro-Nuñez

  3. Department of Endocrinology and Nutrition, Hospital Universitario Infanta Leonor, Madrid, Spain

    Isabel Huguet-Moreno

  4. Department of Endocrinology and Nutrition, Hospital Universitario de la Princesa; Instituto de Investigación Sanitaria Princesa (ISS-IP); Universidad Autónoma de Madrid, Madrid, Spain

    Mónica Marazuela Azpiroz

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  1. José Luis Muñoz de Nova
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  2. Miguel Sampedro-Nuñez
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  3. Isabel Huguet-Moreno
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  4. Mónica Marazuela Azpiroz
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Correspondence to Mónica Marazuela Azpiroz.

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Muñoz de Nova, J.L., Sampedro-Nuñez, M., Huguet-Moreno, I. et al. A practical approach to normocalcemic primary hyperparathyroidism. Endocrine 74, 235–244 (2021). https://doi.org/10.1007/s12020-021-02845-4

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