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The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia

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Abstract

An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.

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Acknowledgements

This study was supported by Associazione Italiana Ricerca sul Cancro (AIRC; IG 13312 and IG18999 to M. Bifulco). E. Ciaglia was supported by a fellowship from Fondazione Umberto Veronesi (FUV 2017, cod.1072).

Author Contributions

M.B. researched data and contributed to the discussion; S.P. researched data and reviewed/edited the manuscript; E.C. researched data, wrote the manuscript and contributed to the discussion. Prof. Maurizio Bifulco is the guarantor of this work and, as such, had full access to all the data in this study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Authors and Affiliations

  1. Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081, Salerno, Italy

    Maurizio Bifulco, Simona Pisanti & Elena Ciaglia

  2. CORPOREA-Fondazione Idis-Città della Scienza, via Coroglio 104 e 57, 80124, Naples, Italy

    Maurizio Bifulco

Authors
  1. Maurizio Bifulco
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  2. Simona Pisanti
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  3. Elena Ciaglia
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Corresponding author

Correspondence to Maurizio Bifulco.

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The authors declare that they have no competing interest.

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Bifulco, M., Pisanti, S. & Ciaglia, E. The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia. Endocrine 58, 21–23 (2017). https://doi.org/10.1007/s12020-017-1254-0

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  • DOI: https://doi.org/10.1007/s12020-017-1254-0

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