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Thyroid hormones alterations during acute liver failure: possible underlying mechanisms and consequences

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An Erratum to this article was published on 28 October 2016

Abstract

Thyroid hormones are now recognized to change in different disease states with important consequences on severity and prognosis of disease. However, little is known about thyroid hormones’ alterations in acute liver failure (ALF). To study the changes in thyroid hormones and cardiac thyroid receptors during ALF, we subjected seven female pigs to surgical liver devascularization. Liver function biochemical markers, thyroid hormones, endogenous opioids, malondialdehyde (MDA), and interleukins 1 and 6 were measured in serum for 24 h postoperatively. Heart biopsies were harvested at the end of the experiment. Baseline heart biopsies were taken from five additional animals. Serum thyroxin (T4) and triiodothyronine (T3) levels markedly decreased, whereas free-triiodothyronine and thyroxin-stimulating hormone levels did not change. T4 and T3 levels correlated with the degree of liver failure and with MDA and interleukin-6 levels. Beta-endorphin levels initially increased, whereas levels of leucine-enkephalin did not change. Thyroid hormone receptor-α1 protein expression in the heart decreased 1.6-fold after ALF, whereas myocardial myosin isoform expression remained unchanged. The downregulation of T4 and T3 levels during ALF seems to correlate well with the severity of disease. This downregulation related to inflammation and oxidative stress and resulted in changes in myocardial thyroid receptors.

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Authors and Affiliations

  1. 2nd Department of Anesthesiology, Attikon Hospital, University of Athens School of Medicine, Rimini 1 Str., Chaidari, Athens, Greece

    Georgia Kostopanagiotou, Konstantinos Kalimeris & Aikaterini Chranioti

  2. Department of Pharmacology, University of Athens School of Medicine, Athens, Greece

    Iordanis Mourouzis, Danai Spanou & Constantinos Pantos

  3. 2nd Department of Surgery, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece

    Constantinos Costopanagiotou, Nikolaos Arkadopoulos, Dimitrios Panagopoulos, Nikolaos Papoutsidakis & Vassilios Smyrniotis

  4. Department of Pathology, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece

    Agatha Pafiti

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  1. Georgia Kostopanagiotou
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Correspondence to Konstantinos Kalimeris.

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An erratum to this article is available at http://dx.doi.org/10.1007/s12020-016-1155-7.

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Kostopanagiotou, G., Kalimeris, K., Mourouzis, I. et al. Thyroid hormones alterations during acute liver failure: possible underlying mechanisms and consequences. Endocr 36, 198–204 (2009). https://doi.org/10.1007/s12020-009-9210-2

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  • DOI: https://doi.org/10.1007/s12020-009-9210-2

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