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Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in Chinese

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Abstract

Polycystic ovary syndrome (PCOS) is a complex multi-factorial disorder involving a number of genetic and environmental factors. CYP1A1 (Cytochrome P450, family 1, subfamily A, polypeptide 1) gene, which belongs to Cytochrome P450 (CYP) super family, encodes a phase I cytochrome P450 enzyme, involved in the oxidative metabolism of estrogens. A recent study suggested that a common polymorphism Ile462Val of the CYP1A1 gene might be associated with PCOS development in Turkish women. To investigate a possible association between the CYP1A1 Ile462Val polymorphism and PCOS in Chinese women, we examined 205 PCOS patients and 177 healthy controls. All subjects were genotyped for CYP1A1. There was no statistical difference in CYP1A1 genotype and allele frequencies between PCOS cases and controls (χ2 = 0.956, df = 2, P = 0.089 by genotype; χ2 = 0.005, df = 1, P = 0.941 by allele). Compared with controls, there were no statistical difference in Val/Val genotype and Val allele frequency in the PCOS cases (4.9% vs. 5.1% by genotype; 51.7% vs. 52.0% by allele) (χ2 = 0.009, df = 1, P = 0.926 by genotype; χ2 = 0.005, df = 1, P = 0.941 by allele). Moreover, no association between CYP1A1 Ile462Val genotypes and metabolic parameters was observed in PCOS women. Our findings clearly indicated that this polymorphism does not represent an additional genetic risk factor for PCOS in Chinese women.

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Acknowledgements

This work was supported by the National Basic Research Program of China (2007CB511905), the National Natural Science Foundation of China (30571954) and the National Infrastructure Program of Chinese Genetic Resources (2006DKA21300).

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Authors and Affiliations

  1. Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, China

    Binbin Wang, Jing Wang, Jingjing Liu, Feng Ni & Yunxia Cao

  2. Center for Genetics, National Research Institute for Family Planning, 100081, Beijing, China

    Binbin Wang, Jing Wang, Jinting Yan, Sirui Zhou, Yuan Mu & Xu Ma

  3. Graduate School, Peking Union Medical College, Beijing, China

    Binbin Wang, Jing Wang, Jinting Yan, Sirui Zhou, Yuan Mu & Xu Ma

  4. World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China

    Xu Ma

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  1. Binbin Wang
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  3. Jingjing Liu
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  4. Feng Ni
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  7. Yuan Mu
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  8. Yunxia Cao
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Correspondence to Yunxia Cao or Xu Ma.

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Binbin Wang and Jing Wang contributed equally to the work.

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Wang, B., Wang, J., Liu, J. et al. Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in Chinese. Endocr 36, 16–19 (2009). https://doi.org/10.1007/s12020-009-9205-z

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