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A case of non-Hodgkin’s lymphoma primary arising in both adrenal glands associated with adrenal failure

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Abstract

It is known that adrenal insufficiency is one of the complications in primary adrenal lymphoma, especially those with bilateral adrenal involvement. A 73-year-old man was referred for general fatigue and high fever to the nearest hospital. The patient was transferred to our hospital for evaluation of bilateral adrenal tumors and hyponatremia. He was diagnosed as having non-Hodgkin’s lymphoma (NHL) with primaries arising in both adrenal glands. Primary adrenal lymphoma (PAL) is a rare extra-nodal NHL. Although an appropriate treatment of this disease has not been established, our case has demonstrated that the combination of rituximab and THP-COP chemotherapy could be administered, and that it improved clinical manifestations. This case raises the suggestion that malignant lymphoma should be suspected in patients with bilateral adrenal tumors that present with progressive adrenal insufficiency.

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Authors and Affiliations

  1. Division of Hematology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan

    Takamasa Nishiuchi, Hitomi Imachi, Mako Fujiwara, Koji Murao, Hiroaki Onishi & Toshihiko Ishida

  2. Department of Internal Medicine, Kagawa Rosai Hospital, Marugame, Kagawa, 763-8502, Japan

    Tohru Kiguchi & Hidetaka Takimoto

  3. Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, 761-0793, Japan

    Yoshio Kushida & Reiji Haba

Authors
  1. Takamasa Nishiuchi
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  2. Hitomi Imachi
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  3. Mako Fujiwara
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  4. Koji Murao
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  5. Hiroaki Onishi
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  6. Tohru Kiguchi
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  7. Hidetaka Takimoto
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  8. Yoshio Kushida
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  9. Reiji Haba
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  10. Toshihiko Ishida
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Corresponding author

Correspondence to Koji Murao.

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Nishiuchi, T., Imachi, H., Fujiwara, M. et al. A case of non-Hodgkin’s lymphoma primary arising in both adrenal glands associated with adrenal failure. Endocr 35, 34–37 (2009). https://doi.org/10.1007/s12020-008-9125-3

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  • DOI: https://doi.org/10.1007/s12020-008-9125-3

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