Abstract
The results of this case-control study conducted at a large HMO support the notion that severe asthma may be associated with transient hepatic enzyme elevation. Conversely, we found no evidence of associations between asthma therapeutic classes and hepatic enzyme elevation.
Similar content being viewed by others
References
Colldahl H. A study of serum enzymes in patients suffering from periods of respiratory insufficiency, especially asthma and emphysema. Acta Med Scand. 1960;166:399.
El-Shaboury AH, Thomas AJ, Williams DA. Serum transaminase activity in status asthmaticus. BMJ. 1964;1:1220–1223.
Samaria JK, Roy DC, Agarwal BV, Matah SC. Profile of serum transaminases in acute bronchial asthma. Indian J Chest Dis Allied Sci. 1986;28:63–65.
Colldahl H. Serum enzymes in patients with asthma and emphysema. Acta Allergol. 1964;19:97–102.
Refsum HE. Arterial hypoxemia, serum activities of GOT, GPT and LDH, and centrilobular necrosis in pulmonary insufficiency. Clin Sci. 1963;25:269–374.
Sundberg M, Ahlqvist J, Kotovirta ML. Serum transaminase activity and liver alterations in bronchial asthma. Acta Allergol. 1968;23:54–68.
Chapman KR, Ljungholm K, Kallen A. Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group. Chest. 1994; 106:1407–1413.
Wald JA, Farr RS. Abnormal liver-function tests associated with long-term systemic corticosteroid use in subjects with asthma. J Allergy Clin Immunol. 1991;88:277–278.
Israel E, Cohn J, Dube L, Drazen JM. Effect of treatment with zileuton, a 5-lipoxygenase inhibtor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA. 1996;275:931–936.
Krieger N. Overcoming the absence of socioeconomic data in medical records: validation and application of a censusbased methodology. Am J Public Health.. 1992;82:703–710.
Lieu TA, Capra AM, Quesenberry CP, Mendoza GR, Mazar M. Computer-based models to identify high-risk adults with asthma: is the glass half empty of half full? J Asthma. 1999; 36:359–370.
Gitlin N. The serum glutamic oxaloacetic transaminase/serum glutamic pyruvic transaminase ratio as a prognostic index in severe acute viral hepatitis. Am J Gastroenterol. 1982;77:2–4.
Majumdar SK, Dias N, Aps EJ. Relationship between hepatic histology and conventional biochemical liver function test in chronic alcoholic patients. Drug Alcohol Depend. 1991;28:211–214.
Shimokawa Y, Okuda K, Kubo Y, et al. Serum glutamic oxalacetic transaminase/glutamic pyruvic transaminase ratios in hepatocellular carcinoma. Cancer. 1977;40:319–324.
Gonzalez-Abraldes J, Sanchez-Fueyo A, Bessa X, et al.. Persistent hypertransaminasemia as the presenting feature of celiac disease. Am J Gastroenterol. 1999;94:1095–1097.
Katon W, Russo J, Ashley RL, Buchwald D. Infectious mononucleosis: psychological symptoms during acute and subacute phases of illness. Gen Hosp Psychiatr. 1999;21:21–29.
Wroblewski F. The clinical significance of transaminase activities in serum. Am J Med. 1959;27:911–923.
Author information
Authors and Affiliations
About this article
Cite this article
Iribarren, C., Sidney, S., Lydick, E. et al. The association between asthma, asthma therapeutic classes and hepatic enzyme elevation among adult HMO members. Compr Ther 27, 133–139 (2001). https://doi.org/10.1007/s12019-996-0007-4
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s12019-996-0007-4