Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

Yu, Wanli; Liang, Sai; Zhang, Chunzhi

doi:10.1007/s12017-018-8507-9

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

Review Paper
Published: 04 September 2018

Volume 20, pages 452–474, (2018)
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Abstract

GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the eight biological capabilities in GBM have made great progress. From these studies, it can be inferred that miRs, as a mode of post-transcriptional regulation, are involved in regulating these malignant biological hallmarks of GBM. Herein, we discuss state-of-the-art research on how aberrant miRs modulate the eight hallmarks of GBM. The upregulation of ‘oncomiRs’ or the genetic loss of tumor suppressor miRs is associated with these eight biological capabilities acquired during GBM formation. Furthermore, we also discuss the applicable clinical potential of these research results. MiRs may aid in the diagnosis and prognosis of GBM. Moreover, miRs are also therapeutic targets of GBM. These studies will develop and improve precision medicine for GBM in the future.

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Wanli Yu and Sai Liang have contributed equally to the present work.

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Department of Radiation Oncology, Tianjin Hospital, Tianjin, 300211, China
Wanli Yu, Sai Liang & Chunzhi Zhang
Tianjin Medical University, Tianjin, 300070, China
Wanli Yu & Sai Liang

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Wanli Yu
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Yu, W., Liang, S. & Zhang, C. Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma. Neuromol Med 20, 452–474 (2018). https://doi.org/10.1007/s12017-018-8507-9

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Received: 19 May 2018
Accepted: 17 August 2018
Published: 04 September 2018
Issue Date: December 2018
DOI: https://doi.org/10.1007/s12017-018-8507-9

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Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

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Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

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Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma

MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway

The role of microRNA-148a and downstream DLGAP1 on the molecular regulation and tumor progression on human glioblastoma

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