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IGF-1R Transported to the Cell Nuclei to Regulate the Proliferation of Breast Cancer Cells

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Abstract

Under normal physiological conditions, IGF-1 (insulin-like growth factor-1) has important biological effects. However, many studies have found that IGF-1 is closely related to the occurrence and development of breast cancer. But up to now, the cellular properties of IGF-1 have not been systematically explored in breast cancer cell. It is well-known that the cellular properties and behaviors of IGF-1/IGF-1R are closely related to its biological functions. In the current study, we used the breast cancer cell line as a model to explore the biological characteristics of IGF-1/IGF-1R, and found that IGF-1/IGF-1R can be internalized into the cytoplasm. In addition, we also found that IGF-1R can also enter cell nuclei under the mediation of IGF-1. Further research found that the nuclear-localized IGF-1R has important potential biological effects, which is closely associated to the proliferation of breast cancer cell, this may be achieved by regulating IGF-1R-mediated intracellular signaling. The current research has laid the foundation for investigating the relationship between IGF-1/IGF-1R system and the occurrence and development of breast cancer.

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Acknowledgements

This work was supported by Jilin Scientific and Technological Development Program [grant no. 20190905003SF], [grant no. 20190701060GH]; China Postdoctoral Science Foundation Grant [grant no. 2019M651216].

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Authors and Affiliations

  1. Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Street, Harbin, 150001, China

    Baoliang Guo

  2. Department of Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China

    Zheng Lv

  3. Department of Breast Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, China

    Chunguo Cui & Wan Wang

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  1. Baoliang Guo
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  2. Zheng Lv
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  3. Chunguo Cui
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  4. Wan Wang
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Correspondence to Wan Wang.

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Guo, B., Lv, Z., Cui, C. et al. IGF-1R Transported to the Cell Nuclei to Regulate the Proliferation of Breast Cancer Cells. Cell Biochem Biophys 79, 801–813 (2021). https://doi.org/10.1007/s12013-021-00989-8

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  • DOI: https://doi.org/10.1007/s12013-021-00989-8

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