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Clinical Factors Associated With the Diagnosis and Progression of Diabetic Nephropathy

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Abstract

As an important complication of diabetic mellitus, diabetic nephropathy (DN) has been the main cause of end-stage renal disease. It is of great importance to diagnose DN early, and to identify the risk factors of disease progression in order to carry out in-time and effective therapies. Previous literatures have reported the role of several clinical factors in the diagnosis and progression of DN, including age, longer diabetes duration, diabetic retinopathy, higher level of hypertension and HbA1c, and so on. However, the significance of these clinical factors is still controversial and limited. This review aimed to evaluate the values and limitations of these factors in diagnosing and predicting the renal outcome of DN.

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Acknowledgments

This study was supported by the 863 program (2012AA02A512), the Twelfth Five-Year National Key Technology R&D Program (2011BAI10B00), 973 program (2013CB530800), and the NSFC (81070267, 81171645).

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There are no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Nephrology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, 100853, China

    Shuang Liang, Han-Yu Zhu, Jian-Hui Zhou, Rui Ding, Xiang-Mei Chen & Guang-Yan Cai

  2. Department of Pediatrics, Chinese PLA 309 Hospital, Beijing, 100091, China

    Qian Li

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  1. Shuang Liang
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  2. Qian Li
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  3. Han-Yu Zhu
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Correspondence to Guang-Yan Cai.

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Shuang Liang and Qian Li contributed equally to this work.

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Liang, S., Li, Q., Zhu, HY. et al. Clinical Factors Associated With the Diagnosis and Progression of Diabetic Nephropathy. Cell Biochem Biophys 70, 9–15 (2014). https://doi.org/10.1007/s12013-014-9892-9

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