Abstract
The objective of the study is to evaluate the clinical significance of screening for fetal spina bifida aperta by ultrasound examination and intracranial translucency (IT) measurement at 11–13+6 weeks of gestation. About 1,479 women at 11–13+6 weeks of gestation in our hospital in 2012 were included as observation group, and 1,608 women at 11–13+6 weeks of gestation without IT measurement in 2011 was included as controls. Detection rates of fetal spina bifida aperta in two groups were compared. The translucency thickness between the brain stem and choroid plexus and crown-rump length (CRL) in mid-sagittal view of the fetal face was measured, and translucency thickness and CRL in fetuses with spina bifida and healthy ones were compared. Detection rate of fetal spina bifida aperta in observation group was significantly higher than that in control group (six cases in observation group and one case in control group, p = 0.046). IT thickness was significantly lower in fetuses with spina bifida aperta (0.01 ± 1.25 mm) than that in healthy ones (1.73 ± 0.32 mm) (p < 0.001). There was positive correlation in healthy fetuses between IT thickness and CRL (r = 0.702, p < 0.001), but not in fetuses with spina bifida aperta (r = 0.001, p = 0.081). Ultrasound examination with IT measurement at 11–13+6 weeks of gestation can be used to screen for fetal spina bifida aperta, and the reduction of IT thickness is an indicator of spina bifida aperta.
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Gu, L. L., & Li, S. L. (2012). Advances in prenatal diagnosis of fetal spina bifida. Chinese Journal of Medical Ultrasound, 9(3), 8–11.
Li, S. L., Gu, L. L., & Wen, H. X. (2011). Prenatal diagnosis and classification of open and closed spina bifida. Chinese Journal of Medical Ultrasound, 8(8), 1632–1646.
Bradley, L. A., Palomaki, G. E., & McDowell, G. A. (2005). Technical standards and guidelines: Prenatal screening for open neural tube defects. Genetics in Medicine, 7(5), 355–369.
Ghi, T., Pilu, G., Falco, P., et al. (2006). Prenatal diagnosis of open and closed spina bifida. Ultrasound in Obstetrics and Gynecology, 28(7), 899–903.
Qin, F. Z., & Li, S. L. (2014). Advances in prenatal screening and diagnosis of open spine bifida at 11-13+6 weeks of gestation. Chinese Journal of Medical Ultrasound, 11(1), 9–13.
Syngelaki, A., Chelemen, T., Dagklis, T., et al. (2011). Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11–13 weeks. Prenatal Diagnosis, 31(1), 90–102.
Nicolaides, K. H., Gabbe, S. G., Campbell, S., et al. (1986). Ultrasound screening for spina bifida: Cranial and cerebellar signs. The Lancet, 328(8498), 72–74.
Chaoui, R., Benoit, B., Mitkowska-Wozniak, H., et al. (2009). Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11–13-week scan[J]. Ultrasound in Obstetrics and Gynecology, 34(3), 249–252.
Huang, Y.M., Ma, X.Y., Huang, D.P., et al. (2011). Ultrasonography detection of intracranial translucency at 11-13 + 6 weeks of gestation. Chinese Journal of Medical Ultrasound, 8(4), 772–777.
Adiego, B., Illescas, T., Martinez-Ten, P., et al. (2012). Intracranial translucency at 11–13 weeks of gestation: Prospective evaluation and reproducibility of measurements. Prenatal Diagnosis, 32(3), 259–263.
Sebire, N. J., Noble, P. L., Thorpe-Beeston, J. G., et al. (1997). Presence of the ‘lemon’ sign in fetuses with spina bifida at the 10–14-week scan. Ultrasound in Obstetrics and Gynecology, 10(6), 403–405.
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Liu, M., Liu, Y., Li, Zh. et al. Screening for Fetal Spina Bifida Aperta by the Ultrasound and Intracranial Translucency Examinations at 11–13+6 Weeks of Gestation. Cell Biochem Biophys 72, 439–441 (2015). https://doi.org/10.1007/s12013-014-0484-5
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DOI: https://doi.org/10.1007/s12013-014-0484-5